Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 4/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4717599 | 0.98 | TAAR1 (0.55) | TAAR1AOC3MPOIDO1ALDH1A1 | |
| SCHEMBL2339717 | 0.85 | TAAR1 (0.41) | TAAR1AOC3MPOIDO1ALDH1A1 | |
| SCHEMBL13988381 | 0.85 | TAAR1 (0.39) | TAAR1AOC3MPOIDO1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3424767 | 0.84 | TAAR1 (0.40) | TAAR1AOC3MPOIDO1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4323161 | 0.83 | TAAR1 (0.38) | TAAR1AOC3MPOIDO1ALDH1A1 | |
| SCHEMBL2859015 | 0.80 | TAAR1 (0.57) | TAAR1AOC3MPOIDO1ALDH1A1 | |
| SCHEMBL1520469 | 0.79 | TAAR1 (0.50) | TAAR1AOC3IDO1ALDH1A1MAOB | |
| SCHEMBL7202777 | 0.78 | TAAR1 (0.42) | TAAR1IDO1HPGDF2 | |
| Hydrochloric Acid SCHEMBL213754 | 0.78 | IDO1 (0.48) | TAAR1AOC3IDO1ALDH1A1MAOB | |
| SCHEMBL4846601 | 0.77 | MPO (0.39) | MPOIDO1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462620-B2 | Pyrimidinone derivatives and their use in the treatment of atherosclerosis | SMITHKLINE BEECHAM, PLC (GB) | 2008-12-09 | — | — | US | disclosed |
| US-20060241126-A1 | Pyrimidinone Derivatives and Their Use in the Treatment of Atherosclerosis | ELLIOTT RICHARD L | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241126-A1 | Pyrimidinone Derivatives and Their Use in the Treatment of Atherosclerosis | PLA2G7, PLA2G1B, PLA2G4B | TAAR1 1034/4885AOC3 460/4885MPO 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.