Sugi Predict

Sugi Predict / Compounds / SCHEMBL2859015

SCHEMBL2859015

SCHEMBL2859015

NC(=O)CCc1ccccc1F

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 3/20 0.57
▸ MPO P05164 4/20 0.55
▸ ALDH1A1 P00352 2/20 0.51
▸ MAOB P27338 2/20 0.50
▸ PARP15 Q460N3 1/20 0.50
▸ PARP14 Q460N5 1/20 0.50
▸ PARP10 Q53GL7 1/20 0.50
▸ AOC3 Q16853 1/20 0.47
▸ CASP3 P42574 1/20 0.47
▸ CASP7 P55210 1/20 0.47
▸ NR3C2 P08235 1/20 0.46
▸ SCN3A Q9NY46 1/20 0.46
▸ MTNR1A P48039 1/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ IDO1 P14902 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5261311 0.90 MPO (0.56) TAAR1MPOALDH1A1MAOBPARP15
SCHEMBL27918771 0.85 MPO (0.50) TAAR1MPOALDH1A1MAOBPARP15
SCHEMBL9321175 0.85 MTNR1A (0.47) MPOALDH1A1MTNR1A
SCHEMBL7331602 0.83 TAAR1 (0.56) TAAR1MPOALDH1A1MAOBPARP15
SCHEMBL25605235 0.82 TAAR1 (0.52) TAAR1MPOMTNR1A
SCHEMBL246473 0.82 MEN1 (0.59) TAAR1ALDH1A1CASP3CASP7MEN1
SCHEMBL6964948 0.82 TAAR1 (0.54) TAAR1MPOALDH1A1MAOBPARP15
SCHEMBL29444401 0.82 MEN1 (0.59) TAAR1ALDH1A1CASP3CASP7MEN1
SCHEMBL11549937 0.80 TAAR1 (0.52) TAAR1MPOALDH1A1MAOBPARP15
SCHEMBL2527059 0.80 TAAR1 (0.52) TAAR1MPOALDH1A1MAOBPARP15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160107997-A1 CXCR7 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2016-04-21 — — US claimed
EP-2513061-A1 PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS H. Lundbeck A/S (DK) 2012-10-24 — — EP claimed
EP-2012767-A2 FORMULATIONS CONTAINING AMIDE DERIVATIVES OF CARBOXYLIC ACID NSAIDS FOR TOPICAL ADMINISTRATION TO THE EYE ALCON INC. (CH) 2009-01-14 — — EP claimed
WO-2007127844-A2 FORMULATIONS CONTAINING AMIDE DERIVATIVES OF CARBOXYLIC ACID NSAIDS FOR TOPICAL ADMINISTRATION TO THE EYE ALCON, INC. (CH) 2007-11-08 — — WO claimed
EP-1351938-A1 PHENYL DERIVATIVES MERCK PATENT GmbH (DE) 2003-10-15 — — EP claimed
WO-2002057236-A1 PHENYL DERIVATIVES MERCK PATENT GMBH (DE) 2002-07-25 — — WO claimed
EP-3632892-B1 METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND SUMITOMO CHEMICAL CO (JP) 2024-07-31 — — EP disclosed
CN-110799490-B 3-arylpropionamide compound and method for producing 3-arylpropionate compound 住友化学株式会社 2023-05-02 — — CN disclosed
US-11028056-B2 Method for producing 3-arylpropionamide compound and 3-arylpropionic acid ester compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2021-06-08 — — US disclosed
US-20200165209-A1 METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND AND 3-ARYLPROPIONIC ACID ESTER COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2020-05-28 — — US disclosed
EP-3632892-A1 METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND AND 3-ARYLPROPIONIC ACID ESTER COMPOUND Sumitomo Chemical Company, Limited (JP) 2020-04-08 — — EP disclosed
CN-110799490-A Process for producing 3-arylpropionamide compound and process for producing 3-arylpropionate compound 住友化学株式会社 2020-02-14 — — CN disclosed
CN-103814021-B Dihydroquinoline 2 ketone derivatives 霍夫曼-拉罗奇有限公司 2016-12-21 — — CN disclosed
US-20080064690-A1 PYRAZOLE-AMIDES AND -SULFONAMIDES ICAGEN, INC. (US) 2008-03-13 — — US disclosed
US-7223782-B2 Pyrazole-amides and -sulfonamides ICAGEN, INC. (US) 2007-05-29 — — US disclosed
US-20050182093-A1 Novel compounds GLAXOSMITHKLINE S.P.A. 2005-08-18 — — US disclosed
US-6894175-B1 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use THE PROCTER & GAMBLE COMPANY (US) 2005-05-17 — — US disclosed
US-20050049237-A1 Pyrazole-amides and -sulfonamides ICAGEN, INC. (US) 2005-03-03 — — US disclosed
EP-1377555-A1 NOVEL COMPOUNDS GlaxoSmithKline S.p.A. (IT) 2004-01-07 — — EP disclosed
WO-2002083645-A1 NOVEL COMPOUNDS GLAXOSMITHKLINE S.P.A. (IT) 2002-10-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160107997-A1 CXCR7 RECEPTOR MODULATORS CXCR1, CXCR5, CXCR2 TAAR1 253/4885MPO 3203/4885ALDH1A1 997/4885
US-20050182093-A1 Novel compounds SLC10A1, AVPR2, REN TAAR1 3952/4885MPO 2574/4885ALDH1A1 1675/4885
US-20080064690-A1 PYRAZOLE-AMIDES AND -SULFONAMIDES SCN3A, TRPV3, HCN3 TAAR1 2571/4885MPO 2602/4885ALDH1A1 3589/4885
US-20050049237-A1 Pyrazole-amides and -sulfonamides SCN3A, TRPV3, HCN3 TAAR1 2571/4885MPO 2602/4885ALDH1A1 3589/4885
US-20200165209-A1 METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND AND 3-ARYLPROPIONIC ACID ESTER COMPOUND AADAC, DDT, NAT1 TAAR1 26/4885MPO 3648/4885ALDH1A1 116/4885
US-11028056-B2 Method for producing 3-arylpropionamide compound and 3-arylpropionic acid ester compound AADAC, DDT, NAT1 TAAR1 26/4885MPO 3648/4885ALDH1A1 116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.