Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RGS4 | P49798 | 1/20 | 0.47 |
| ▸ | RGS8 | P57771 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446255 | 0.75 | CNR1 (0.60) | CNR1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28474139 | 0.75 | ALDH1A1 (0.50) | MAPTALDH1A1TP53SMN1; SMN2MAPK8 | |
| SCHEMBL8985073 | 0.74 | GSK3B (0.67) | MAPTALDH1A1SMN1; SMN2RGS4RGS8 | |
| SCHEMBL18931677 | 0.73 | HPGD (0.55) | CNR1MAPTALDH1A1RGS4RGS8 | |
| SCHEMBL27888661 | 0.73 | ALDH1A1 (0.49) | ALDH1A1TP53SMN1; SMN2LMNAHTT | |
| SCHEMBL4214380 | 0.72 | MAPT (0.53) | MAPTALDH1A1TP53RGS4RGS8 | |
| SCHEMBL24004722 | 0.72 | TSHR (0.76) | MAPTALDH1A1TP53MAPK8MAPK9 | |
| SCHEMBL11719377 | 0.72 | P2RX3 (0.54) | MAPTALDH1A1TP53SMN1; SMN2RGS4 | |
| SCHEMBL7142622 | 0.71 | MAPT (0.52) | CNR1MAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL10487926 | 0.71 | MEN1 (0.61) | MAPTTP53MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183949-B2 | Pyrimidinone derivative having autotaxin-inhibitory activity | THE UNIVERSITY OF TOKYO (JP) | 2019-01-22 | — | — | US | disclosed |
| US-20170158704-A1 | PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY | THE UNIVERSITY OF TOKYO (JP) | 2017-06-08 | — | — | US | disclosed |
| US-7452892-B2 | Triazolopyrimidine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-18 | — | — | US | disclosed |
| US-7452892-B2 | Triazolopyrimidine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-18 | — | — | US | disclosed |
| US-7452892-B2 | Triazolopyrimidine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-18 | — | — | US | disclosed |
| US-20060287341-A1 | Triazolopyrimidine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287341-A1 | Triazolopyrimidine cannabinoid receptor 1 antagonists | CNR1, CNR2, GPR68 | CNR1 1/4885MAPT 2322/4885ALDH1A1 1549/4885 |
| US-20170158704-A1 | PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY | ENPP2, ITPA, IMPA1 | CNR1 3959/4885MAPT 2150/4885ALDH1A1 3520/4885 |
| US-10183949-B2 | Pyrimidinone derivative having autotaxin-inhibitory activity | ENPP2, ITPA, IMPA1 | CNR1 3959/4885MAPT 2150/4885ALDH1A1 3520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.