Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142682 | 0.86 | ALDH1A1 (0.50) | MAPTTP53LMNATHRBKDM4E | |
| SCHEMBL10838564 | 0.78 | KDM4E (0.48) | MAPTGAALMNADPP4KDM4E | |
| SCHEMBL18701258 | 0.73 | ALDH1A1 (0.42) | MAPTPOLBGAALMNAKDM4E | |
| SCHEMBL10854437 | 0.71 | ADORA2B (0.45) | MAPTTP53GAALMNAKDM4E | |
| SCHEMBL4841964 | 0.71 | CNR1 (0.51) | MAPTTP53LMNAKDM4EALDH1A1 | |
| SCHEMBL9764106 | 0.69 | ALDH1A1 (0.43) | MAPTTP53ALOX5PTGS1GAA | |
| SCHEMBL4616581 | 0.69 | CYP1A2 (0.42) | MAPTTP53ALOX5PTGS1GAA | |
| SCHEMBL29143951 | 0.67 | LMNA (0.50) | MAPTPOLBGAALMNAKDM4E | |
| SCHEMBL27567770 | 0.67 | NTRK1 (0.52) | MAPTLMNADPP4KDM4EALDH1A1 | |
| SCHEMBL2673231 | 0.66 | TYMP (0.50) | MAPTGAALMNADPP4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | claimed |
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |