Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ENPEP | Q07075 | 3/20 | 0.43 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11600199 | 0.87 | LMNA (0.53) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL7149918 | 0.85 | FOLH1 (0.52) | LMNASLC22A6TSHRNFKB1ENPEP | |
| SCHEMBL887688 | 0.82 | LMNA (0.53) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL10659380 | 0.81 | TSHR (0.41) | LMNASLC22A6TSHRFOLH1GABRR1 | |
| SCHEMBL7352946 | 0.81 | LMNA (0.46) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL23829834 | 0.79 | LMNA (0.43) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL10474509 | 0.79 | TSHR (0.39) | LMNASLC22A6TSHRFOLH1GABRR1 | |
| SCHEMBL28099127 | 0.79 | SLC22A6 (0.35) | LMNASLC22A6TSHRFOLH1GABRR1 | |
| SCHEMBL1554385 | 0.79 | AKR1B1 (0.46) | LMNASLC22A6TSHRENPEPKMT2A | |
| SCHEMBL6464981 | 0.79 | GPR84 (0.50) | SLC22A6TSHRKMT2AHDAC11GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371854-B2 | Method for the production of bicyclic aromatic amino acids and intermediate products thereof | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | disclosed |
| US-20060142568-A1 | Method for the production of bicyclic aromatic amino acids and intermediate products thereof | MEREK PATENT GMBH (DE) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142568-A1 | Method for the production of bicyclic aromatic amino acids and intermediate products thereof | ITGA1, ITGB1, ITGA2 | LMNA 1778/4885SLC22A6 4048/4885TSHR 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.