Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TNFSF10 | P50591 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | HEXA | P06865 | 1/20 | 0.38 |
| ▸ | HEXB | P07686 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699598 | 0.86 | KDM4E (0.49) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL4844072 | 0.82 | KDM4E (0.49) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL7818543 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL7699109 | 0.75 | CYP1A2 (0.50) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL27409908 | 0.75 | CYP1A2 (0.49) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL8659206 | 0.74 | ALDH1A1 (0.41) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL5179425 | 0.74 | RXFP1 (0.42) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL8961804 | 0.74 | RAB9A (0.69) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL5592998 | 0.72 | MAPT (0.52) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A | |
| SCHEMBL8660654 | 0.72 | LMNA (0.58) | CYP1A2CYP2C19KMT2ACYP2C9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743307-B1 | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-5739333-A | 4-SULFONAMIDO-6-ARYLOXY OR -AMINOALKYLENEOXY,-AMINO, OR -THIOPYRIMIDINES; ENDOLTHELIN ANTAGONISTS; HYPOTENSIVE AND ULCER AGENTS; ASTHMA; RAYNAUD DISEASE; CARDIOVASCULAR DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0743307-A1 | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1996-11-20 | — | — | EP | disclosed |