Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.37 |
| ▸ | SPTLC2 | O15270 | 2/20 | 0.37 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484795 | 0.95 | SPTLC2 (0.42) | ALPIALPGPOLBTAS1R3TAS1R1 | |
| SCHEMBL2817168 | 0.91 | ALPI (0.40) | ALPIALPGPOLBTAS1R3TAS1R1 | |
| SCHEMBL485466 | 0.90 | SPTLC2 (0.43) | ALPIALPGPOLBTAS1R3TAS1R1 | |
| SCHEMBL484966 | 0.90 | ALPI (0.39) | ALPIALPGPOLBMEN1KMT2A | |
| SCHEMBL484393 | 0.87 | TDP1 (0.38) | ALPIALPGPOLBTAS1R3TAS1R1 | |
| SCHEMBL2818512 | 0.85 | ALPI (0.40) | ALPIALPGPOLBMEN1KMT2A | |
| SCHEMBL484426 | 0.85 | CYP2C9 (0.38) | TAS1R3TAS1R1TAS1R2ACKR3BDKRB1 | |
| SCHEMBL484832 | 0.84 | ACHE (0.42) | POLBTAS1R3TAS1R1TAS1R2ACKR3 | |
| SCHEMBL485266 | 0.84 | P2RX7 (0.39) | TAS1R3TAS1R1TAS1R2ACKR3KCNH2 | |
| SCHEMBL484780 | 0.84 | CYP2D6 (0.44) | TAS1R3TAS1R1TAS1R2SPTLC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | claimed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | claimed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | claimed |
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | ALPI 4482/4885ALPG 4815/4885POLB 4589/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | ALPI 4482/4885ALPG 4815/4885POLB 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.