Sugi Predict

Sugi Predict / Compounds / SCHEMBL4846403

SCHEMBL4846403

SCHEMBL4846403

CCC(O)(c1cccs1)c1cc(Nc2cccc(Cl)c2)ccc1N

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.38
▸ MEN1 O00255 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ PGR P06401 3/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ HPGD P15428 2/20 0.36
▸ FADS1 O60427 4/20 0.34
▸ EGFR P00533 2/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ KDM1A O60341 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ POLB P06746 2/20 0.33
▸ KDM4E B2RXH2 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3986047 0.75 POLB (0.36) MAPTMEN1KMT2APOLBALDH1A1
SCHEMBL11622213 0.64 PGR (0.42) MEN1KMT2APGRNPSR1MAPK1
SCHEMBL10365870 0.64 CA2 (0.46) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL1686631 0.63 FADS1 (0.59) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL3799300 0.62 MAPT (0.59) MAPTMEN1KMT2AFADS1EGFR
SCHEMBL27463664 0.61 CHRM3 (0.42) MEN1KMT2ASMN1; SMN2
SCHEMBL5684867 0.60 ESR1 (0.41) MAPTKMT2AKDM4EALDH1A1GAA
SCHEMBL28855768 0.60 ESR1 (0.41) MAPTKMT2AKDM4EALDH1A1GAA
SCHEMBL24131432 0.60 PGR (0.45) MAPTKMT2APGRHPGDMAPK1
SCHEMBL8883646 0.60 FADS1 (0.53) MAPTMEN1KMT2ARAB9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7354915-B2 6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2008-04-08 — — US disclosed
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-09-27 — — US disclosed
US-7247625-B2 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-07-24 — — US disclosed
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH 2005-04-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 MAPT 4773/4885MEN1 3752/4885KMT2A 3143/4885
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 MAPT 4773/4885MEN1 3752/4885KMT2A 3143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.