Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462178 | 0.83 | TAAR1 (0.61) | TAAR1MAP4K4SMARCA2PBRM1ADORA2A | |
| SCHEMBL29433577 | 0.83 | TAAR1 (0.61) | TAAR1MAP4K4SMARCA2PBRM1ADORA2A | |
| Hydrochloric Acid SCHEMBL1014896 | 0.81 | TAAR1 (0.59) | TAAR1MAP4K4SMARCA2PBRM1ADORA2A | |
| SCHEMBL30417076 | 0.74 | TAAR1 (0.55) | TAAR1SMARCA2PBRM1ADORA2AMAPT | |
| SCHEMBL27883785 | 0.73 | PRMT6 (0.44) | TAAR1ADORA2AKEAP1MAPTKDM4E | |
| SCHEMBL28217068 | 0.72 | TAAR1 (0.58) | TAAR1SMARCA2PBRM1KEAP1MAPT | |
| SCHEMBL1161258 | 0.70 | TAAR1 (1.00) | TAAR1ADORA2AMAPTKDM4EALDH1A1 | |
| SCHEMBL28874633 | 0.70 | TAAR1 (0.66) | TAAR1ADORA2AKEAP1MAPTKDM4E | |
| Aniline SCHEMBL2657203 | 0.70 | TAAR1 (0.73) | TAAR1SMARCA2PBRM1ADORA2AKEAP1 | |
| SCHEMBL15519549 | 0.70 | TAAR1 (0.61) | TAAR1SMARCA2PBRM1ADORA2AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442705-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC PHARMACEUTICALS LTD (IE) | 2008-10-28 | — | — | US | disclosed |
| EP-1597238-B1 | HIV REPLICATION INHIBITING PYRIMIDINES AND TRIAZINES | TIBOTEC PHARM LTD (IE) | 2007-05-09 | — | — | EP | disclosed |
| US-20060194804-A1 | Hiv replication inhibiting pyrimidines and triazines | TIBOTEC BVBA | 2006-08-31 | — | — | US | disclosed |
| EP-1597238-A1 | HIV REPLICATION INHIBITING PYRIMIDINES AND TRIAZINES | Tibotec Pharmaceuticals Ltd. (IE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074262-A1 | HIV REPLICATION INHIBITING PYRIMIDINES AND TRIAZINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194804-A1 | Hiv replication inhibiting pyrimidines and triazines | TYMS, UMPS, DUT | TAAR1 3302/4885MAP4K4 2338/4885SMARCA2 2883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.