Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 5/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023687 | 1.00 | TACR1 (0.47) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL13479127 | 0.97 | CTSS (0.49) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL13479128 | 0.96 | TACR1 (0.46) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL13479129 | 0.95 | TACR1 (0.43) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL13479135 | 0.95 | TACR1 (0.43) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL14497710 | 0.95 | CTSS (0.46) | TACR1CTSSCTSKCTSBMAPT | |
| SCHEMBL14497715 | 0.94 | CTSS (0.42) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL4889692 | 0.94 | CTSB (0.47) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL13479136 | 0.93 | CTSS (0.42) | TACR1SYKSCN9ACTSSCTSK | |
| SCHEMBL14497714 | 0.93 | CTSS (0.45) | TACR1SYKSCN9ACTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446102-B2 | Antibacterial amide macrocycles IV | AICURIS GMBH & CO. KG (DE) | 2008-11-04 | — | — | US | disclosed |
| US-20080076745-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO. KG (DE) | 2008-03-27 | — | — | US | disclosed |
| US-20070129288-A1 | Antibacterial amide macrocycles | BAYER HEALTHCARE AG (DE) | 2007-06-07 | — | — | US | disclosed |
| US-20060258571-A1 | Antibacterial ester macrocycles | AICURIS GMBH & CO. KG (DE) | 2006-11-16 | — | — | US | disclosed |
| US-20050256037-A1 | Antibacterial amide macrocyles | BAYER HEALTHCARE AG (DE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129288-A1 | Antibacterial amide macrocycles | AADAC, AAAS, MRPL21 | TACR1 2316/4885SYK 3831/4885SCN9A 3190/4885 |
| US-20080076745-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | NOD2, AAAS, AADAC | TACR1 2730/4885SYK 3060/4885SCN9A 3327/4885 |
| US-20050256037-A1 | Antibacterial amide macrocyles | AADAC, PAM, NOD2 | TACR1 2610/4885SYK 3666/4885SCN9A 3972/4885 |
| US-20060258571-A1 | Antibacterial ester macrocycles | TECR, MRPL21, CYP51A1 | TACR1 2875/4885SYK 1443/4885SCN9A 3984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.