Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484763 | 0.85 | HTT (0.53) | HPGDITGB3ITGA2BALDH1A1TSHR | |
| SCHEMBL14996487 | 0.83 | HTT (0.57) | HPGDITGB3ITGA2BGRM5ALDH1A1 | |
| SCHEMBL18046881 | 0.82 | ITGB3 (0.54) | ITGB3ITGA2BGRM5TSHRLMNA | |
| SCHEMBL27752273 | 0.80 | HPGD (0.72) | HPGDGRM5ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL22394198 | 0.79 | GRM5 (0.63) | HPGDITGB3ITGA2BGRM5ALDH1A1 | |
| SCHEMBL13131245 | 0.79 | CHRNB2 (0.56) | HPGDITGB3ITGA2BGRM5ALDH1A1 | |
| SCHEMBL13131026 | 0.79 | HPGD (0.50) | HPGDITGB3ITGA2BGRM5ALDH1A1 | |
| Hydrochloric Acid SCHEMBL485406 | 0.78 | CHRNB2 (0.55) | HPGDITGB3ITGA2BGRM5ALDH1A1 | |
| SCHEMBL2677418 | 0.78 | ALDH1A1 (0.48) | HPGDITGB3ITGA2BGRM5ALDH1A1 | |
| SCHEMBL493733 | 0.77 | HPGD (0.61) | HPGDGRM5ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | HPGD 386/4885ITGB3 3292/4885ITGA2B 3190/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | HPGD 386/4885ITGB3 3292/4885ITGA2B 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.