Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 13/20 | 0.47 |
| ▸ | RARG | P13631 | 13/20 | 0.47 |
| ▸ | RXRA | P19793 | 11/20 | 0.47 |
| ▸ | RARA | P10276 | 10/20 | 0.47 |
| ▸ | RXRB | P28702 | 8/20 | 0.47 |
| ▸ | RXRG | P48443 | 7/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292577 | 0.84 | RARB (0.51) | RARBRARGRXRARARARXRB | |
| SCHEMBL803657 | 0.83 | PDK2 (0.47) | CYP26A1CYP3A4 | |
| SCHEMBL17283097 | 0.79 | CA12 (0.48) | RARBRARGRARACYP3A4 | |
| SCHEMBL6937210 | 0.77 | MAPT (0.54) | CYP3A4 | |
| SCHEMBL568994 | 0.75 | PGR (0.55) | — | |
| SCHEMBL8771776 | 0.75 | RARB (0.43) | TDP2RARBRARGRXRARARA | |
| SCHEMBL8771635 | 0.75 | TDP2 (0.42) | TDP2RARBRARGRXRARARA | |
| SCHEMBL8771793 | 0.75 | RARB (0.48) | RARBRARGRXRARARARXRB | |
| SCHEMBL8771833 | 0.74 | RARB (0.52) | RARBRARGRXRARARA | |
| SCHEMBL9139650 | 0.74 | RARB (0.73) | TDP2RARBRARGRXRARARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |