Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 8/20 | 0.41 |
| ▸ | RARB | P10826 | 7/20 | 0.40 |
| ▸ | RARG | P13631 | 6/20 | 0.40 |
| ▸ | RXRB | P28702 | 5/20 | 0.40 |
| ▸ | RARA | P10276 | 4/20 | 0.40 |
| ▸ | RXRG | P48443 | 4/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485022 | 0.75 | TDP2 (0.50) | TDP2RXRARARBRARGRXRB | |
| SCHEMBL6292577 | 0.73 | RARB (0.51) | RXRARARBRARGRXRBRARA | |
| SCHEMBL8771776 | 0.71 | RARB (0.43) | TDP2RXRARARBRARGRXRB | |
| SCHEMBL8771792 | 0.70 | CA12 (0.40) | TDP2RXRARARBRARGRXRB | |
| SCHEMBL23617815 | 0.69 | ACHE (0.60) | TDP2TDP1KDM4EMAPTALDH1A1 | |
| SCHEMBL11864151 | 0.68 | ALDH1A1 (0.47) | TDP2TDP1KDM4EALDH1A1POLB | |
| SCHEMBL8771867 | 0.68 | RARB (0.46) | RXRARARBRARGRARAALDH1A1 | |
| SCHEMBL8771910 | 0.66 | TDP2 (0.43) | TDP2RXRARARBRARGRXRB | |
| SCHEMBL15890863 | 0.66 | NOTUM (0.46) | KDM4EMAPTPOLBCYP2C19 | |
| SCHEMBL15890864 | 0.66 | NOTUM (0.46) | KDM4EMAPTPOLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |