Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.48 |
| ▸ | RARG | P13631 | 14/20 | 0.48 |
| ▸ | RARA | P10276 | 13/20 | 0.48 |
| ▸ | RXRA | P19793 | 5/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771941 | 0.87 | RARA (0.66) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL12365183 | 0.76 | SRD5A2 (0.53) | KMO | |
| SCHEMBL485022 | 0.75 | TDP2 (0.50) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8771650 | 0.74 | RARB (0.77) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL8028154 | 0.72 | RXRA (0.59) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8771833 | 0.70 | RARB (0.52) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL8771825 | 0.69 | RARB (0.41) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL17275573 | 0.69 | RARB (0.50) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL8028156 | 0.68 | RARA (0.60) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL2744011 | 0.68 | GRIK1 (0.57) | RARBRARGRARARXRAKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |