Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.43 |
| ▸ | RARG | P13631 | 10/20 | 0.43 |
| ▸ | RARA | P10276 | 7/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 11/20 | 0.42 |
| ▸ | RXRB | P28702 | 9/20 | 0.42 |
| ▸ | RXRG | P48443 | 6/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1071564 | 0.80 | RXRA (0.46) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL6814070 | 0.79 | RARB (0.41) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL6814457 | 0.77 | PBRM1 (0.39) | TDP2 | |
| SCHEMBL8632757 | 0.76 | AKR1B1 (0.41) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL23617815 | 0.75 | ACHE (0.60) | TDP2 | |
| SCHEMBL485022 | 0.75 | TDP2 (0.50) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL6292577 | 0.73 | RARB (0.51) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL8903275 | 0.72 | MAPT (0.41) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL4521166 | 0.71 | OPRK1 (0.45) | — | |
| SCHEMBL8771635 | 0.71 | TDP2 (0.42) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |