Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 5/20 | 0.46 |
| ▸ | JUN | P05412 | 4/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.46 |
| ▸ | RELA | Q04206 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23297112 | 0.97 | NFKB1 (0.44) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL29498463 | 0.84 | NFKB1 (0.40) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL31002408 | 0.79 | JUN (0.36) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL23802503 | 0.79 | JUN (0.36) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL1740256 | 0.77 | KIF11 (0.54) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL17742 | 0.75 | NR1H2 (0.42) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL11394539 | 0.74 | TSHR (0.35) | NFKB1JUNNFKB2RELA | |
| SCHEMBL11287557 | 0.74 | KMT2A (0.39) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL32663089 | 0.73 | CYP11B2 (0.45) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL22869183 | 0.73 | CYP11B2 (0.45) | NFKB1JUNNFKB2RELAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026106499-A1 | OREXIN RECEPTOR ANTAGONISTS: 2-AZABICYCLIC COMPOUNDS | BIAL - PORTELA & CA., S.A. (PT) | 2026-05-21 | — | — | WO | claimed |
| EP-4688155-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | Bial-Portela & CA, S.A. (PT) | 2026-02-11 | — | — | EP | claimed |
| EP-4688154-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | BIAL - Portela & Ca., S.A. (PT) | 2026-02-11 | — | — | EP | claimed |
| WO-2025023852-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | BIAL - PORTELA & CA., S.A. (PT) | 2025-01-30 | — | — | WO | claimed |
| WO-2025023851-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | BIAL - PORTELA & CA., S.A. (PT) | 2025-01-30 | — | — | WO | claimed |
| US-20230295144-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | UNIV ZHEJIANG (CN) | 2023-09-21 | — | — | US | claimed |
| US-20210284625-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | UNIV ZHEJIANG (CN) | 2021-09-16 | — | — | US | claimed |
| EP-3530657-A1 | 2-POLYSUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE AND PREPARATION AND MEDICAL USE | Zhejiang University (CN) | 2019-08-28 | — | — | EP | claimed |
| CN-109988116-A | A kind of synthetic method of 2- methylol -5- trifluoromethyl pyrimidine | 上海吉奉生物科技有限公司 | 2019-07-09 | — | — | CN | claimed |
| US-10087147-B2 | 5-(trifluoromethyl)pyrimidine derivatives and method for producing same | TOSOH F-TECH, INC. (JP) | 2018-10-02 | — | — | US | claimed |
| CN-108503592-A | A kind of synthetic method of bis- chloro- 5- trifluoromethyl pyrimidines of fluorine-containing miazines medicine intermediate 2,4- | 浙江科聚生物医药有限公司 | 2018-09-07 | — | — | CN | claimed |
| US-20170217906-A1 | 5-(TRIFLUOROMETHYL)PYRIMIDINE DERIVATIVES AND METHOD FOR PRODUCING SAME | TOSOH F-TECH, INC. (JP) | 2017-08-03 | — | — | US | claimed |
| CN-106588884-A | 2-polysubstituted aromatic ring-pyrimidine derivative and preparation and medical application | 浙江大学 | 2017-04-26 | — | — | CN | claimed |
| CN-106479758-A | A kind of integrated circuit board flux cleaning agent and preparation method thereof | 佛山迅拓奥科技有限公司 | 2017-03-08 | — | — | CN | claimed |
| CN-105753790-A | A synthetic method of a medical intermediate 2,4-dichloro-5-trifluoromethylpyrimidine | 无锡乾浩生物医药有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-102224144-B | Sulfone-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as a medicine | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-10-15 | — | — | CN | claimed |
| CN-101792420-B | Preparation of halogenated n-heteroaromatic polyhalogen derivatives | SALTIGO GMBH (DE) | 2014-10-08 | — | — | CN | claimed |
| CN-103119026-A | Process for preparing pan-cdk inhibitors of the formula (l), and intermediates in the preparation | BAYER IP GMBH | 2013-05-22 | — | — | CN | claimed |
| CN-102197029-A | Sulfoximine-substituted anilinopyrimidine derivatives as CDK inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG | 2011-09-21 | — | — | CN | claimed |
| CN-101792420-A | Preparation of halogenated n-heteroaromatic polyhalogen derivatives | SALTIGO GMBH | 2010-08-04 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295144-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | CHEK1, PLK1, CHEK2 | NFKB1 1075/4885JUN 2716/4885NFKB2 1284/4885 |
| US-20210284625-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | CHEK1, PLK1, CHEK2 | NFKB1 1075/4885JUN 2716/4885NFKB2 1284/4885 |
| US-20170217906-A1 | 5-(TRIFLUOROMETHYL)PYRIMIDINE DERIVATIVES AND METHOD FOR PRODUCING SAME | DPYD, DHFR, TYMS | NFKB1 3793/4885JUN 623/4885NFKB2 3814/4885 |
| US-10087147-B2 | 5-(trifluoromethyl)pyrimidine derivatives and method for producing same | DPYD, DHFR, TYMS | NFKB1 3793/4885JUN 623/4885NFKB2 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.