Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | NMBR | P28336 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 2/20 | 0.45 |
| ▸ | FPR1 | P21462 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6247580 | 0.93 | OPRL1 (0.52) | OPRL1OPRM1KMT2ANMBRMAPT | |
| Citric Acid SCHEMBL4857675 | 0.93 | OPRL1 (0.44) | OPRL1OPRM1KMT2AMEN1HCRTR1 | |
| SCHEMBL4852054 | 0.87 | OPRL1 (0.55) | OPRL1OPRM1KMT2AMEN1NMBR | |
| SCHEMBL2378945 | 0.86 | KMT2A (0.57) | OPRL1OPRM1KMT2AMEN1HCRTR1 | |
| SCHEMBL2380119 | 0.86 | KMT2A (0.57) | OPRL1OPRM1KMT2AMEN1HCRTR1 | |
| Hydrochloric Acid SCHEMBL302554 | 0.86 | KMT2A (0.56) | OPRL1OPRM1KMT2AMEN1HCRTR1 | |
| Hydrochloric Acid SCHEMBL2378939 | 0.86 | KMT2A (0.56) | OPRL1OPRM1KMT2AMEN1HCRTR1 | |
| Potassium SCHEMBL2378910 | 0.86 | KMT2A (0.56) | OPRL1OPRM1KMT2AMEN1HCRTR1 | |
| SCHEMBL2378906 | 0.86 | KMT2A (0.56) | OPRL1OPRM1KMT2AMEN1HCRTR1 | |
| Hydrochloric Acid SCHEMBL5176757 | 0.84 | OPRL1 (0.55) | OPRL1OPRM1KMT2AMEN1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348354-B2 | Cyclohexylurea compounds | GRUENENTHAL GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| EP-1560809-B1 | CYCLOHEXYLUREA DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| US-7173045-B2 | 4-aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2007-02-06 | — | — | US | disclosed |
| US-20050261358-A1 | antinociceptive agent of opioid-receptor for treating pain; tert-aminecyclohexyl-urea, or -thiourea, or -amide derivatives; 1-(4-dimethylamino-4-phenylcyclohexyl)-3-(3-phenylpropyl)urea hydrochloride; stereoisomers; racemic mixtures | GRUENENTHAL GMBH (DE) | 2005-11-24 | — | — | US | disclosed |
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2005-11-03 | — | — | US | disclosed |
| EP-1562891-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-17 | — | — | EP | disclosed |
| EP-1560809-A1 | CYCLOHEXYLUREA DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043909-A1 | CYCLOHEXYLUREA DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004043899-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | HNMT, PNMT, INMT | OPRL1 378/4885OPRM1 69/4885KMT2A 295/4885 |
| US-20050261358-A1 | antinociceptive agent of opioid-receptor for treating pain; tert-aminecyclohexyl-urea, or -thiourea, or -amide derivatives; 1-(4-dimethylamino-4-phenylcyclohexyl)-3-(3-phenylpropyl)urea hydrochloride; stereoisomers; racemic mixtures | OPRL1, OPRM1, OGFRL1 | OPRL1 1/4885OPRM1 2/4885KMT2A 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.