Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.62 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.62 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23108168 | 0.92 | GPR119 (0.58) | CYP3A4GPR119CYP11B2MEN1KMT2A | |
| SCHEMBL23108169 | 0.90 | HSD17B10 (0.61) | CYP3A4GPR119CYP11B2MEN1KMT2A | |
| SCHEMBL23742297 | 0.86 | CYP11B2 (0.56) | CYP3A4GPR119CYP11B2MEN1KMT2A | |
| SCHEMBL484915 | 0.85 | HSD17B10 (0.65) | CYP3A4GPR119CYP11B2MEN1KMT2A | |
| SCHEMBL484867 | 0.84 | CYP11B2 (0.54) | CYP3A4GPR119CYP11B2HSD17B10TSHR | |
| SCHEMBL15570718 | 0.84 | GPR119 (0.60) | CYP3A4GPR119CYP11B2MEN1KMT2A | |
| SCHEMBL12964579 | 0.82 | GPR119 (0.77) | CYP3A4GPR119HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL29461446 | 0.82 | HSD17B10 (0.69) | CYP3A4GPR119CYP11B2MEN1KMT2A | |
| SCHEMBL484102 | 0.81 | HIF1A (0.63) | CYP3A4CYP11B2MEN1KMT2AHSD17B10 | |
| SCHEMBL28614518 | 0.81 | CYP11B2 (0.51) | CYP3A4GPR119CYP11B2MAPTSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | CYP3A4 3781/4885GPR119 206/4885CYP11B2 2150/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | CYP3A4 3781/4885GPR119 206/4885CYP11B2 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.