Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845580 | 0.91 | SLC6A9 (0.49) | HTR7ALDH1A1SMN1; SMN2KDM4ESLC6A9 | |
| SCHEMBL4852186 | 0.85 | SLC6A9 (0.46) | HTR7ALDH1A1KDM4ESLC6A9ADRB2 | |
| SCHEMBL4855017 | 0.84 | KDM4E (0.49) | HTR7ALDH1A1SMN1; SMN2KDM4ESLC6A9 | |
| SCHEMBL4851155 | 0.80 | SLC6A9 (0.46) | HTR7ALDH1A1SMN1; SMN2KDM4ESLC6A9 | |
| SCHEMBL4854461 | 0.79 | DRD2 (0.46) | ALDH1A1KDM4ESLC6A9DRD2DRD1 | |
| SCHEMBL5735316 | 0.78 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHR | |
| SCHEMBL4888000 | 0.78 | ALDH1A1 (0.69) | HTR7ALDH1A1SMN1; SMN2KDM4EADRB2 | |
| SCHEMBL4854610 | 0.78 | ALDH1A1 (0.49) | HTR7ALDH1A1SMN1; SMN2KDM4ESLC6A9 | |
| SCHEMBL4853912 | 0.78 | HTR7 (0.54) | HTR7ALDH1A1SMN1; SMN2KDM4ESLC6A9 | |
| SCHEMBL4856307 | 0.78 | HTR7 (0.48) | HTR7ALDH1A1SMN1; SMN2KDM4ESLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |
| EP-1515940-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003097574-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |