SCHEMBL4854848

SCHEMBL4854848

Cc1cc(C)c(N=CC=Nc2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 4/20 0.38
ALDH1A1 P00352 4/20 0.36
CYP3A4 P08684 1/20 0.34
ADRA2A P08913 1/20 0.34
KDM4E B2RXH2 2/20 0.32
LMNA P02545 2/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
HTT P42858 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2A6 P11509 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
TSHR P16473 1/20 0.30
F2 P00734 1/20 0.30
PRSS1 P07477 1/20 0.30
PRSS2 P07478 1/20 0.30
PRSS3 P35030 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14457987 1.00 RAPGEF4 (0.38) RAPGEF4ALDH1A1CYP3A4ADRA2AKDM4E
SCHEMBL4854841 1.00 RAPGEF4 (0.38) RAPGEF4ALDH1A1CYP3A4ADRA2AKDM4E
SCHEMBL13987030 1.00 RAPGEF4 (0.38) RAPGEF4ALDH1A1CYP3A4ADRA2AKDM4E
SCHEMBL29395663 0.81 RAPGEF4 (0.36) RAPGEF4ALDH1A1CYP3A4ADRA2AKDM4E
SCHEMBL17669763 0.79 RAPGEF4 (0.35) RAPGEF4ALDH1A1CYP3A4ADRA2AKDM4E
SCHEMBL21860490 0.77
SCHEMBL23644548 0.77 KMT2A (0.33) RAPGEF4ALDH1A1GAAKMT2A
SCHEMBL23644547 0.77 KMT2A (0.33) RAPGEF4ALDH1A1GAAKMT2A
SCHEMBL11856863 0.75 RAPGEF4 (0.37) RAPGEF4ALDH1A1CYP3A4ADRA2A
SCHEMBL11281680 0.75 CYP3A4 (0.57) RAPGEF4ALDH1A1CYP3A4ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4247900-A1 ZINC PIGMENT FOR WATERBORNE CORROSION COATINGS Sun Chemical Corporation (US) 2023-09-27 EP claimed
WO-2022132845-A1 ZINC PIGMENT FOR WATERBORNE CORROSION COATINGS SUN CHEMICAL CORPORATION (US) 2022-06-23 WO claimed
US-20250242340-A1 SABRE CATALYSTS CONTAINING FLUORINATED CARBON CHAINS FOR DELIVERY OF METAL-FREE MRI CONTRAST AGENTS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) 2025-07-31 US disclosed
US-20250244419-A1 INFUSION DEVICE FOR THE PREPARATION AND DELIVERY OF MRI PROBES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) 2025-07-31 US disclosed
EP-4529456-A1 CHELATING AGENTS FOR USE IN CANCER THERAPY Pleco Therapeutics B.V. (NL) 2025-04-02 EP disclosed
EP-4504404-A2 SABRE CATALYSTS CONTAINING FLUORINATED CARBON CHAINS FOR DELIVERY OF METAL-FREE MRI CONTRAST AGENTS The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2025-02-12 EP disclosed
EP-4505201-A1 INFUSION DEVICE FOR THE PREPARATION AND DELIVERY OF MRI PROBES The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2025-02-12 EP disclosed
CN-119213327-A Infusion device for preparing and delivering MRI probes 美国卫生和人力服务部 2024-12-27 CN disclosed
US-20240216900-A1 SABRE CATALYSTS CONTAINING FLUORINATED CARBON CHAINS FOR DELIVERY OF METAL-FREE MRI CONTRAST AGENTS THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-07-04 US disclosed
US-20240091752-A1 PROCESSES FOR ISOTOPIC MODIFICATION OF POLYUNSATURATED FATTY ACIDS AND DERIVATIVES THEREOF BIOJIVA LLC (US) 2024-03-21 US disclosed
CN-117586188-A Chiral N-imidazoline carbene and preparation method and application thereof 苏州源起材料科技有限公司 2024-02-23 CN disclosed
WO-2023112847-A1 ORGANOSILOXANE-BASED HYDROGEN STORAGE COMPOSITION 国立大学法人東京大学 2023-06-22 WO disclosed
EP-4107163-A1 PROCESSES FOR ISOTOPIC MODIFICATION OF POLYUNSATURATED FATTY ACIDS AND DERIVATIVES THEREOF Retrotope, Inc. (US) 2022-12-28 EP disclosed
WO-2022132845-A1 ZINC PIGMENT FOR WATERBORNE CORROSION COATINGS SUN CHEMICAL CORPORATION (US) 2022-06-23 WO disclosed
CN-110186835-B On-chip microfluidic processing of particles GPB科学有限公司 2022-05-31 CN disclosed
US-9656256-B2 N-heterocyclic carbene type palladium catalyst and its preparation method as well as applications SHANGHAI RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) 2017-05-23 US disclosed
US-20160175828-A1 N-HETEROCYCLIC CARBENE TYPE PALLADIUM CATALYST AND ITS PREPARATION METHOD AS WELL AS APPLICATIONS SHANGHAI RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) 2016-06-23 US disclosed
US-7470750-B2 Method for the degradation of nitrile rubber by metathesis in the presence of ruthenium- or osmium-based catalysts LANXESS DEUTSCHLAND GMBH (DE) 2008-12-30 US disclosed
US-20070049700-A1 Method for the degradation of nitrile rubber by metathesis in the presence of ruthenium- or osmium-based catalysts LANXESS DEUTSCHLAND GMBH (DE) 2007-03-01 US disclosed
WO-2005035121-A2 SCHIFF BASE METAL COMPLEXES FOR USE AS CATALYSTS IN ORGANIC SYNTHESIS UNIVERSITEIT GENT (BE) 2005-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250244419-A1 INFUSION DEVICE FOR THE PREPARATION AND DELIVERY OF MRI PROBES MPI, HAMP, HIF1A RAPGEF4 1420/4885ALDH1A1 3474/4885CYP3A4 1446/4885
US-20240216900-A1 SABRE CATALYSTS CONTAINING FLUORINATED CARBON CHAINS FOR DELIVERY OF METAL-FREE MRI CONTRAST AGENTS FABP7, FFAR1, FABP1 RAPGEF4 4067/4885ALDH1A1 4484/4885CYP3A4 4655/4885
US-20240091752-A1 PROCESSES FOR ISOTOPIC MODIFICATION OF POLYUNSATURATED FATTY ACIDS AND DERIVATIVES THEREOF FASN, FADS1, FADS2 RAPGEF4 2175/4885ALDH1A1 913/4885CYP3A4 719/4885
US-20250242340-A1 SABRE CATALYSTS CONTAINING FLUORINATED CARBON CHAINS FOR DELIVERY OF METAL-FREE MRI CONTRAST AGENTS FABP7, FFAR1, FABP1 RAPGEF4 4067/4885ALDH1A1 4484/4885CYP3A4 4655/4885
US-20160175828-A1 N-HETEROCYCLIC CARBENE TYPE PALLADIUM CATALYST AND ITS PREPARATION METHOD AS WELL AS APPLICATIONS DDC, AOC1, GNE RAPGEF4 3735/4885ALDH1A1 1151/4885CYP3A4 3474/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.