Sugi Predict

Sugi Predict / Compounds / SCHEMBL4854980

SCHEMBL4854980

SCHEMBL4854980

[NH]C(=O)CCS(=O)(=O)c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 4/20 0.65
▸ L3MBTL1 Q9Y468 1/20 0.59
▸ POLB P06746 4/20 0.54
▸ MAPT P10636 1/20 0.51
▸ HDAC3 O15379 1/20 0.51
▸ HDAC4 P56524 1/20 0.51
▸ HDAC1 Q13547 1/20 0.51
▸ HDAC7 Q8WUI4 1/20 0.51
▸ HDAC2 Q92769 1/20 0.51
▸ HDAC10 Q969S8 1/20 0.51
▸ HDAC11 Q96DB2 1/20 0.51
▸ HDAC8 Q9BY41 1/20 0.51
▸ HDAC6 Q9UBN7 1/20 0.51
▸ HDAC9 Q9UKV0 1/20 0.51
▸ HDAC5 Q9UQL6 1/20 0.51
▸ RAB9A P51151 5/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ HTT P42858 1/20 0.51
▸ KMT2A Q03164 2/20 0.51
▸ NPC1 O15118 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7773642 0.89 HDAC1 (0.57) HSD11B1L3MBTL1POLBMAPTHDAC3
SCHEMBL7771538 0.87 HDAC1 (0.64) HSD11B1L3MBTL1POLBMAPTHDAC3
SCHEMBL7770886 0.85 HDAC1 (0.67) HSD11B1L3MBTL1POLBMAPTHDAC3
SCHEMBL7773674 0.85 HDAC1 (0.67) HSD11B1L3MBTL1POLBMAPTHDAC3
SCHEMBL1001018 0.83 HSD11B1 (0.69) HSD11B1L3MBTL1POLBMAPTHDAC3
Hydrochloric Acid SCHEMBL10584023 0.82 HSD11B1 (0.67) HSD11B1L3MBTL1POLBMAPTHDAC3
SCHEMBL9595885 0.81 KMT2A (0.61) POLBMAPTKMT2ACA12CA1
SCHEMBL9626048 0.80 HSD11B1 (0.65) HSD11B1L3MBTL1POLBMAPTHDAC3
SCHEMBL1161573 0.80 HSD11B1 (0.65) HSD11B1L3MBTL1POLBMAPTHDAC3
SCHEMBL6915414 0.80 ALDH1A1 (0.66) HSD11B1L3MBTL1POLBMAPTHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4948879-A Monoazo compounds containing a fiber-reactive group and an oxazolopyridone or oxazinopyridone coupling component HOECHST AKTIENGESELLSCHAFT (DE) 1990-08-14 — — US claimed
EP-1606268-B1 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS ABBVIE INC (US) 2015-05-20 — — EP disclosed
US-7456169-B2 Heterocyclic kinase inhibitors ABBOTT LABORATORIES INC. (US) 2008-11-25 — — US disclosed
US-20070254867-A1 Heterocyclic Kinase Inhibitors ABBVIE INC. 2007-11-01 — — US disclosed
EP-1368528-B1 PROTECTION OF REDUCTION-SENSITIVE DYES CLARIANT FINANCE BVI LTD (VG) 2007-10-17 — — EP disclosed
EP-1606268-A1 HETEROCYCLIC KINASE INHIBITORS Abbott Laboratories (US) 2005-12-21 — — EP disclosed
US-6926746-B2 Protection of reduction-sensitive dyes CLARIANT FINANCE (BVI) LIMITED (VG) 2005-08-09 — — US disclosed
US-20040254159-A1 Heterocyclic kinase inhibitors ABBOTT LABORATORIES 2004-12-16 — — US disclosed
WO-2004076424-A1 HETEROCYCLIC KINASE INHIBITORS ABBOTT LABORATORIES (US) 2004-09-10 — — WO disclosed
US-20040074017-A1 Protection of reduction-sensitive dyes CLARIANT FINANCE (BVI) LIMITED (VG) 2004-04-22 — — US disclosed
US-4559059-A REACTIVE DYES BONDED TO POLYMER CIBA-GEIGY CORPORATION (US) 1985-12-17 — — US disclosed
US-4553975-A REACTING A DYE WITH COPOLYMER GEL CIBA GEIGY CORPORATION (US) 1985-11-19 — — US disclosed
US-4515596-A Process for aftertreating dyed fibrous material made of or containing cellulose CIBA-GEIGY CORPORATION (US) 1985-05-07 — — US disclosed
US-4468229-A Tinted contact lenses and a method for their preparation with reactive dyes CIBA-GEIGY CORPORATION (US) 1984-08-28 — — US disclosed
US-4314812-A Two-phase printing process for preparing conversion articles and discharge resist prints HOECHST AKTIENGESELLSCHAFT (DE) 1982-02-09 — — US disclosed
US-4314811-A Two-phase printing process for preparing conversion articles and discharge resist prints HOECHST AKTIENGESELLSCHAFT (DE) 1982-02-09 — — US disclosed
EP-0030786-A2 Textile colouration process and textiles coloured thereby IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-06-24 — — EP disclosed
US-4092101-A Process for fixing prints with reactive dyestuffs on textile materials of native or regenerated cellulose and mixtures thereof with synthetic fibers HOECHST AKTIENGESELLSCHAFT (DT) 1978-05-30 — — US disclosed
US-4017256-A FIBER DYEABLE WITH DISPERSE DYES AND FIBER DYEABLE WITH REACTIVE DYES CIBA-GEIGY CORPORATION (US) 1977-04-12 — — US disclosed
US-3951588-A Process for dyeing and printing or optical brightening of cellulose materials CIBA-GEIGY CORPORATION (US) 1976-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040254159-A1 Heterocyclic kinase inhibitors MAP3K20, MAP3K19, MAP3K1 HSD11B1 2576/4885L3MBTL1 2937/4885POLB 2556/4885
US-20070254867-A1 Heterocyclic Kinase Inhibitors MAP3K20, MAP3K19, MAP4K2 HSD11B1 3728/4885L3MBTL1 3156/4885POLB 1933/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.