Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HEXA | P06865 | 2/20 | 0.33 |
| ▸ | HEXB | P07686 | 2/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852834 | 0.83 | RGS4 (0.47) | RGS4PTGS1PTGS2MGLLFAAH | |
| SCHEMBL4851652 | 0.80 | RGS4 (0.40) | RGS4HEXAHEXBOGAALDH1A1 | |
| SCHEMBL3469706 | 0.79 | RGS4 (0.50) | RGS4PTGS1PTGS2MGLLFAAH | |
| SCHEMBL18919456 | 0.74 | RGS4 (0.40) | RGS4SIRT1 | |
| SCHEMBL22920989 | 0.72 | HEXA (0.39) | SIRT1DYRK3RPS6KB1EPHA2FLT4 | |
| SCHEMBL3470129 | 0.72 | RGS4 (0.53) | RGS4MGLLTSHRALDH1A1MEN1 | |
| SCHEMBL10282631 | 0.71 | SIRT1 (0.60) | SIRT1DYRK3RPS6KB1EPHA2FLT4 | |
| SCHEMBL22824824 | 0.70 | MGLL (0.67) | PTGS1PTGS2MGLLFAAHTSHR | |
| SCHEMBL4852057 | 0.69 | RGS4 (0.50) | RGS4HEXAHEXBALDH1A1MEN1 | |
| SCHEMBL4845878 | 0.68 | RGS4 (0.46) | RGS4HEXAHEXBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378419-B2 | 9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2008-05-27 | — | — | US | disclosed |
| EP-1664055-B9 | 9-AMINO-PODOPHYLLOTOXIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SERVIER LAB (FR) | 2007-10-10 | — | — | EP | disclosed |
| EP-1664055-B1 | 9-AMINO-PODOPHYLLOTOXIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SERVIER LAB (FR) | 2006-12-13 | — | — | EP | disclosed |
| US-20060247246-A1 | 9-Amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247246-A1 | 9-Amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | SIK2, PTK2B, PLK2 | RGS4 3547/4885SIRT1 4284/4885DYRK3 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.