Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576844 | 0.82 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4EGAAFPR2 | |
| SCHEMBL7584774 | 0.79 | MAPT (0.46) | ALDH1A1SMN1; SMN2AKR1C3AKR1C2KDM4E | |
| SCHEMBL4854150 | 0.75 | MAPT (0.44) | ALDH1A1SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL27567259 | 0.75 | MDM2 (0.43) | ALDH1A1SMN1; SMN2AKR1C3AKR1C2MDM2 | |
| SCHEMBL27567385 | 0.74 | MDM2 (0.42) | ALDH1A1SMN1; SMN2AKR1C3AKR1C2MDM2 | |
| SCHEMBL2482459 | 0.72 | MEN1 (0.57) | ALDH1A1SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL13240820 | 0.72 | MEN1 (0.57) | ALDH1A1SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL3816437 | 0.72 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2MDM2KDM4EGAA | |
| Hydrochloric Acid SCHEMBL2484358 | 0.71 | MEN1 (0.56) | ALDH1A1SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL9298520 | 0.70 | CNR1 (0.53) | ALDH1A1SMN1; SMN2MDM2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432296-B2 | Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds | GRUENENTHAL GMBH (DE) | 2008-10-07 | — | — | US | claimed |
| EP-1596856-B1 | DRUGS CONTAINING SUBSTITUTED 2-ARYL-AMINOACETIC ACID COMPOUNDS AND/OR SUBSTITUTED 2-HETEROARYL-AMINOACETIC ACID COMPOUNDS | GRUENENTHAL GMBH (DE) | 2006-12-13 | — | — | EP | claimed |
| US-20060035959-A1 | Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds | GRUENENTHAL GMBH (DE) | 2006-02-16 | — | — | US | claimed |
| EP-1596856-A2 | DRUGS CONTAINING SUBSTITUTED 2-ARYL-AMINOACETIC ACID COMPOUNDS AND/OR SUBSTITUTED 2-HETEROARYL-AMINOACETIC ACID COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-23 | — | — | EP | claimed |
| WO-2004071381-A2 | DRUGS CONTAINING SUBSTITUTED 2-ARYL-AMINOACETIC ACID COMPOUNDS AND/OR SUBSTITUTED 2-HETEROARYL-AMINOACETIC ACID COMPOUNDS | Grünenthal GmbH (DE) | 2004-08-26 | — | — | WO | claimed |
| US-7432296-B2 | Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds | GRUENENTHAL GMBH (DE) | 2008-10-07 | — | — | US | disclosed |
| EP-1596856-B1 | DRUGS CONTAINING SUBSTITUTED 2-ARYL-AMINOACETIC ACID COMPOUNDS AND/OR SUBSTITUTED 2-HETEROARYL-AMINOACETIC ACID COMPOUNDS | GRUENENTHAL GMBH (DE) | 2006-12-13 | — | — | EP | disclosed |
| US-20060035959-A1 | Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds | GRUENENTHAL GMBH (DE) | 2006-02-16 | — | — | US | disclosed |
| EP-1596856-A2 | DRUGS CONTAINING SUBSTITUTED 2-ARYL-AMINOACETIC ACID COMPOUNDS AND/OR SUBSTITUTED 2-HETEROARYL-AMINOACETIC ACID COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004071381-A2 | DRUGS CONTAINING SUBSTITUTED 2-ARYL-AMINOACETIC ACID COMPOUNDS AND/OR SUBSTITUTED 2-HETEROARYL-AMINOACETIC ACID COMPOUNDS | Grünenthal GmbH (DE) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035959-A1 | Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds | AADAT, DDC, SLC1A2 | ALDH1A1 501/4885SMN1; SMN2 309/4885AKR1C3 1146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.