SCHEMBL4856979

SCHEMBL4856979

CC(C)(C)c1ccc(-c2c(O)cccc2O)c(C(C)(C)C)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
ALDH1A1 P00352 7/20 0.47
ALOX15 P16050 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
HSD17B10 Q99714 2/20 0.47
HPGD P15428 1/20 0.47
TSHR P16473 1/20 0.44
MAPT P10636 3/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
GAA P10253 1/20 0.43
PKM P14618 1/20 0.43
RECQL P46063 1/20 0.43
CA2 P00918 1/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
PLA2G1B P04054 1/20 0.41
NFKB1 P19838 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29388693 0.81 ALDH1A1 (0.47) HDAC4HDAC2HDAC8ALDH1A1ALOX15
SCHEMBL228138 0.79 ALDH1A1 (0.53) ALDH1A1ALOX15TDP1HSD17B10HPGD
SCHEMBL18063625 0.79 ALDH1A1 (0.42) HDAC4HDAC2HDAC8ALDH1A1ALOX15
SCHEMBL7710060 0.78 CNR1 (0.46) HDAC4HDAC2HDAC8ALDH1A1ALOX15
SCHEMBL2357462 0.78 ALDH1A1 (0.48) ALDH1A1ALOX15TDP1HSD17B10HPGD
SCHEMBL29763177 0.78 ALDH1A1 (0.48) ALDH1A1ALOX15TDP1HSD17B10HPGD
SCHEMBL5665795 0.77 ALDH1A1 (0.61) HDAC4HDAC2HDAC8ALDH1A1ALOX15
Phosphoric Acid SCHEMBL8160502 0.77 ALDH1A1 (0.42) HDAC4HDAC2HDAC8ALDH1A1ALOX15
SCHEMBL8708320 0.76 HSD17B1 (0.42) HDAC4HDAC2HDAC8ALDH1A1ALOX15
SCHEMBL29091704 0.76 ALDH1A1 (0.52) HDAC4HDAC2HDAC8ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1449836-B1 LOW DUSTING CRYSTAL TRANSFORMATIONS OF 2, 2'-METHYLENBIS 4-(1,1,3,3-TETRAMETHYLBUTYL)-6-BENZOTRIAZOLYLPHENOL AND MIXTURE THEREOF, METHOD FOR PREPARING THEM, AND ULTRAVIOLET ABSORBENT USING THE SAME CHEMIPRO KASEI KAISHA LTD (JP) 2008-06-11 EP disclosed
US-7326744-B2 Low dusting crystal transformations of 2,2′-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] and mixture thereof, method for preparing them, and ultraviolet light absorber using them CHEMPIRO KAEI KAISHA, LIMITED (JP) 2008-02-05 US disclosed
US-7317046-B2 Cyclic phosphazenes, process for preparing them, flame retardant containing them as active ingredient, and resin composition containing them and molded article therefrom CHEMIPRO KASEI KAISHA, LIMITED (JP) 2008-01-08 US disclosed
US-20040242733-A1 Low dusting crystal transformations of 2,2'-methylenbis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] and mixture thereof, method for preparing them, and ultraviolet absorbent using the same CHEMIPRO KASEI KAISHA, LIMITED (JP) 2004-12-02 US disclosed
EP-1449836-A1 LOW DUSTING CRYSTAL TRANSFORMATIONS OF 2, 2'-METHYLENBIS 4-(1,1,3,3-TETRAMETHYLBUTYL)-6-BENZOTRIAZOLYLPHENOL AND MIXTURE THEREOF, METHOD FOR PREPARING THEM, AND ULTRAVIOLET ABSORBENT USING THE SAME Chemipro Kasei Kaisha, Limited (JP) 2004-08-25 EP disclosed
US-20040152910-A1 Cyclic phosphazenes, process for preparing them, flame retardants containing the same as the active ingredient, and resin composition containing and molded articles containing the flame retardants CHEMIPRO KASEI KAISHA, LIMITED (JP) 2004-08-05 US disclosed
EP-1403273-A1 CYCLIC PHOSPHAZENES, PROCESS FOR PREPARING THEM, FLAME RETARDANTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT, AND RESIN COMPOSITIONS AND MOLDED ARTICLES CONTAINING THE FLAME RETARDANTS Chemipro Kasei Kaisha, Limited (JP) 2004-03-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040152910-A1 Cyclic phosphazenes, process for preparing them, flame retardants containing the same as the active ingredient, and resin composition containing and molded articles containing the flame retardants PFAS, AFF1, PHOSPHO1 HDAC4 2816/4885HDAC2 1569/4885HDAC8 3112/4885
US-20040242733-A1 Low dusting crystal transformations of 2,2'-methylenbis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] and mixture thereof, method for preparing them, and ultraviolet absorbent using the same TRRAP, TTI2, TTI1 HDAC4 1401/4885HDAC2 2770/4885HDAC8 3091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.