Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8090629 | 0.88 | CA2 (0.44) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11772725 | 0.79 | GABRA1 (0.54) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11646260 | 0.78 | GABRA1 (0.52) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11954818 | 0.76 | GABRA1 (0.50) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9586549 | 0.74 | GABRA1 (0.48) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1160000 | 0.74 | GABRA1 (0.48) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30460531 | 0.74 | TRPA1 (0.38) | ALDH1A1KDM4ESMN1; SMN2CA2SCN2A | |
| SCHEMBL8138383 | 0.73 | GABRA1 (0.47) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL12163543 | 0.73 | GABRA1 (0.47) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4857593 | 0.73 | GABRA1 (0.47) | GABRA1GABRB2ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456126-B2 | Ziegler-natta catalyst for olefin polymerization including aryloxy group and method for polymerization of olefin using same | SAMSUNG TOTAL PETROCHEMICALS CO., LTD. (KR) | 2008-11-25 | — | — | US | disclosed |
| US-20070179048-A1 | Ziegler-natta catalyst for olefin polymerization including aryloxy group and method for polymerization of olefin using same | SAMSUNG TOTAL PETROCHEMICALS CO., LTD (KR) | 2007-08-02 | — | — | US | disclosed |
| WO-2005049659-A1 | ZIEGLER-NATTA CATALYST FOR OLEFIN POLYMERIZATION INCLUDING ARYLOXY GROUP AND METHOD FOR POLYMERIZATION OF OLEFIN USING THE SAME | SAMSUNG ATOFINA CO. LTD. (KR) | 2005-06-02 | — | — | WO | disclosed |