Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4857585 | 0.88 | GABRA1 (0.47) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL28357983 | 0.74 | CA2 (0.46) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL727522 | 0.74 | CA2 (0.46) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL3096012 | 0.73 | CA2 (0.50) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL30503394 | 0.71 | CA2 (0.48) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL10650288 | 0.71 | CA2 (0.48) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL12488403 | 0.71 | CA2 (0.48) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL30921753 | 0.71 | CA2 (0.48) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL2855725 | 0.71 | CA2 (0.48) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL2855727 | 0.71 | CA2 (0.48) | CA2GABRA1GABRB2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143845-A | USING CATALYST MIXTURE OF TRANSITION-METAL COMPOUND HAVING LIGAND WITH CONJUGATED PI ELECTRON, ALUMINOXANE, AND A DIHYDROCARBYLOXY MAGNESIUM OR HYDROCARBYLOXYMAGNESIUM HALIDE; REGULATION OF MOLECULAR WEIGHT(MW) DISTRIBUTION, HIGH MW | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0609439-B1 | PROCESS FOR PRODUCING POLYOLEFIN | IDEMITSU PETROCHEMICAL CO (JP) | 1996-11-27 | — | — | EP | disclosed |
| EP-0609439-A1 | PROCESS FOR PRODUCING POLYOLEFIN | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 1994-08-10 | — | — | EP | disclosed |