Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | MMP9 | P14780 | 1/20 | 0.62 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | F7 | P08709 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037714 | 1.00 | ALDH1A1 (0.64) | ALDH1A1HTTLMNASMN1; SMN2MMP9 | |
| SCHEMBL7931673 | 0.86 | MMP9 (0.64) | ALDH1A1MMP9HCRTR1TDP1F7 | |
| SCHEMBL3523094 | 0.86 | MMP9 (0.64) | ALDH1A1MMP9HCRTR1TDP1F7 | |
| SCHEMBL1143366 | 0.86 | MMP9 (0.64) | ALDH1A1MMP9HCRTR1TDP1F7 | |
| SCHEMBL18068729 | 0.86 | MMP9 (0.64) | ALDH1A1MMP9HCRTR1TDP1F7 | |
| SCHEMBL15671578 | 0.84 | MMP9 (0.47) | ALDH1A1HTTLMNASMN1; SMN2MMP9 | |
| SCHEMBL12354758 | 0.84 | MMP9 (0.61) | ALDH1A1HTTMMP9HCRTR1TDP1 | |
| SCHEMBL9002961 | 0.84 | ALDH1A1 (0.68) | ALDH1A1HTTLMNASMN1; SMN2MMP9 | |
| SCHEMBL18137208 | 0.82 | MMP9 (0.59) | ALDH1A1MMP9HCRTR1TDP1F7 | |
| SCHEMBL8339684 | 0.82 | HCRTR1 (0.62) | SMN1; SMN2MMP9HCRTR1TDP1F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407960-B2 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1806346-A1 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | CV THERAPEUTICS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |
| US-20070004751-A1 | Substituted heterocyclic compounds | ELZEIN ELFATIH | 2007-01-04 | — | — | US | disclosed |
| US-7125876-B2 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-20040152890-A1 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152890-A1 | Substituted heterocyclic compounds | KCNH1, SDHA, COQ8A | ALDH1A1 245/4885HTT 2557/4885LMNA 2835/4885 |
| US-20070004751-A1 | Substituted heterocyclic compounds | KCNH1, SDHA, COQ8A | ALDH1A1 281/4885HTT 2259/4885LMNA 2300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.