Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA3 | P07451 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29489333 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EHSD17B10CA12 | |
| SCHEMBL31392596 | 0.85 | PDE3B (0.56) | ALDH1A1HPGDKDM4EHSD17B10CA12 | |
| SCHEMBL9342415 | 0.85 | PDE3B (0.56) | ALDH1A1HPGDKDM4EHSD17B10CA12 | |
| SCHEMBL9211923 | 0.74 | NCEH1 (0.57) | ALDH1A1CA2RAB9AGAAMEN1 | |
| SCHEMBL12186 | 0.74 | CYP1A2 (0.44) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL10580705 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EHSD17B10CA12 | |
| SCHEMBL8799093 | 0.72 | PDE3B (0.77) | ALDH1A1HPGDKDM4EHSD17B10CA12 | |
| SCHEMBL16595870 | 0.71 | NOS1 (0.45) | ALDH1A1KDM4ECYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29447161 | 0.71 | CYP1A2 (0.79) | KDM4ECA12CA1CA7CA9 | |
| SCHEMBL443070 | 0.71 | CYP1A2 (0.79) | KDM4ECA12CA1CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393960-B2 | Indoles having anti-diabetic activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1546142-A4 | INDOLES HAVING ANTI-DIABETIC ACTIVITY | MERCK & CO INC (US) | 2007-10-17 | — | — | EP | disclosed |
| US-20050272788-A1 | peroxisome proliferator activated receptor agonist such as (2R)-2-(3-{[3-(4-chlorophenoxy)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl}phenoxy)butanoic acid, used for treatment and control of metabilic disorders | MERCK SHARP & DOHME CORP. | 2005-12-08 | — | — | US | disclosed |
| EP-1546142-A2 | INDOLES HAVING ANTI-DIABETIC ACTIVITY | Merck & Co., Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004019869-A2 | INDOLES HAVING ANTI-DIABETIC ACTIVITY | MERCK & CO., INC. (US) | 2004-03-11 | — | — | WO | disclosed |
| US-4053318-A | SENSITIZING MEROCYANINE DYE | FUJI PHOTO FILM CO., LTD. (JA) | 1977-10-11 | — | — | US | disclosed |
| US-4047964-A | BENZISOXAZOLE | FUJI PHOTO FILM CO., LTD. (JA) | 1977-09-13 | — | — | US | disclosed |
| US-4021251-A | Silver halide photographic emulsions | FUJI PHOTO FILM CO., LTD. (JA) | 1977-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272788-A1 | peroxisome proliferator activated receptor agonist such as (2R)-2-(3-{[3-(4-chlorophenoxy)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl}phenoxy)butanoic acid, used for treatment and control of metabilic disorders | PPARA, GPR119, PPARG | ALDH1A1 1448/4885HPGD 1384/4885KDM4E 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.