Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9413729 | 0.85 | TDP1 (0.47) | TDP1SIRT3SSTR4POLBKDM4C | |
| SCHEMBL21582000 | 0.83 | SIRT3 (0.50) | TDP1SIRT3SSTR4POLBKDM4C | |
| SCHEMBL377258 | 0.82 | ALDH1A1 (0.39) | TDP1SIRT3KDM4CALDH1A1KDM4E | |
| SCHEMBL27916164 | 0.80 | ACHE (0.46) | TDP1SIRT3SSTR4POLBALDH1A1 | |
| SCHEMBL7603934 | 0.78 | CA12 (0.39) | TDP1SIRT3KDM4CALDH1A1KDM4E | |
| SCHEMBL4633528 | 0.77 | ALDH1A1 (0.53) | TDP1SIRT3KDM4CALDH1A1KDM4E | |
| SCHEMBL9320822 | 0.77 | GAA (0.41) | TDP1KDM4CCCNCCDK8ALDH1A1 | |
| SCHEMBL9318384 | 0.76 | SLC22A12 (0.51) | KMT2A | |
| SCHEMBL9413735 | 0.74 | CYP2E1 (0.38) | TDP1KDM4CCCNCCDK8ALDH1A1 | |
| SCHEMBL4633602 | 0.73 | ALDH1A1 (0.48) | TDP1SIRT3KDM4CALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411363-B1 | SUBSTITUTED PIPERIDINES AS PAR-1 ANTAGONISTS | BAYER IP GMBH (DE) | 2015-10-07 | — | — | EP | disclosed |
| EP-2411363-A1 | SUBSTITUTED PIPERIDINES AS PAR-1 ANTAGONISTS | Bayer Pharma AG (DE) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108608-A1 | SUBSTITUTED PIPERIDINES AS PAR-1 ANTAGONISTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-09-30 | — | — | WO | disclosed |