Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 9/20 | 0.46 |
| ▸ | HTR2C | P28335 | 9/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950542 | 0.81 | L3MBTL1 (0.63) | L3MBTL1NAMPTTP53MAPTNPC1 | |
| SCHEMBL29573760 | 0.81 | HTR2A (0.70) | HTR2AHTR2C | |
| SCHEMBL5057350 | 0.81 | HTR2A (0.70) | HTR2AHTR2C | |
| SCHEMBL4859619 | 0.79 | SMN1; SMN2 (0.56) | L3MBTL1RXFP1TP53MAPTNPC1 | |
| SCHEMBL6490218 | 0.77 | L3MBTL1 (0.54) | L3MBTL1RXFP1TP53MAPTNPC1 | |
| SCHEMBL29573278 | 0.77 | HTR2A (0.70) | HTR2AHTR2C | |
| SCHEMBL2949934 | 0.77 | NPC1 (0.60) | L3MBTL1NAMPTMAPTNPC1RAB9A | |
| SCHEMBL5061771 | 0.77 | HTR2A (0.70) | HTR2AHTR2C | |
| SCHEMBL23019558 | 0.74 | RORC (0.61) | L3MBTL1NAMPTRXFP1RORC | |
| SCHEMBL2960922 | 0.73 | L3MBTL1 (0.57) | L3MBTL1NAMPTMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558582-B1 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2005-12-21 | — | — | EP | disclosed |