Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 6/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201910 | 0.77 | NPC1 (0.42) | CNR2HTR6HRH2NPC1MEN1 | |
| SCHEMBL6378962 | 0.76 | HRH2 (0.34) | CNR2HTR6HRH2NPC1MEN1 | |
| SCHEMBL4860169 | 0.73 | MAPT (0.40) | HTR6HRH2NPC1MEN1KMT2A | |
| SCHEMBL5205702 | 0.70 | CNR1 (0.37) | CNR2HRH2MAPT | |
| SCHEMBL2966921 | 0.67 | TP53 (0.59) | CNR2KMT2ARXFP1LMNAMAPT | |
| SCHEMBL4858356 | 0.67 | CREBBP (0.42) | HRH2ALDH1A1 | |
| SCHEMBL2972386 | 0.64 | NPC1 (0.54) | CNR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL5203731 | 0.64 | PDE2A (0.41) | ALDH1A1 | |
| SCHEMBL5205358 | 0.62 | ALDH1A1 (0.45) | HRH2KMT2AALDH1A1 | |
| SCHEMBL5202293 | 0.61 | THRB (0.49) | HRH2MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368470-B2 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2008-05-06 | — | — | US | disclosed |