Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203872 | 0.88 | TPSAB1 (0.48) | PDE2APROKR1CNR1TPSAB1ALDH1A1 | |
| SCHEMBL5202357 | 0.85 | SLC2A1 (0.55) | PROKR1HSD11B1TPSAB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5201910 | 0.78 | NPC1 (0.42) | CNR1 | |
| SCHEMBL4858356 | 0.75 | CREBBP (0.42) | HSD11B1CNR1ALDH1A1 | |
| SCHEMBL5202510 | 0.74 | HSD11B1 (0.55) | PROKR1HSD11B1CNR1TPSAB1ALDH1A1 | |
| SCHEMBL5204238 | 0.72 | HSD11B1 (0.47) | HSD11B1ALDH1A1SMN1; SMN2SLC2A1 | |
| SCHEMBL5206419 | 0.72 | SMN1; SMN2 (0.49) | PROKR1HSD11B1CNR1TPSAB1ALDH1A1 | |
| SCHEMBL5204533 | 0.72 | ALDH1A1 (0.46) | PROKR1HSD11B1TPSAB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5202100 | 0.72 | ALDH1A1 (0.51) | PDE2APROKR1HSD11B1CNR1TPSAB1 | |
| SCHEMBL5204500 | 0.71 | TPSAB1 (0.47) | PROKR1CNR1TPSAB1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |