Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201910 | 0.81 | NPC1 (0.42) | CNR1CNR2HRH2MAPTHTT | |
| SCHEMBL4860169 | 0.72 | MAPT (0.40) | HRH2MAPT | |
| SCHEMBL4860164 | 0.70 | CNR2 (0.36) | CNR2HRH2MAPT | |
| SCHEMBL5203731 | 0.69 | PDE2A (0.41) | CNR1HSD11B1 | |
| SCHEMBL5202510 | 0.69 | HSD11B1 (0.55) | CNR1HSD11B1HRH2HTT | |
| SCHEMBL4858356 | 0.68 | CREBBP (0.42) | CNR1HSD11B1HRH2 | |
| SCHEMBL4862667 | 0.68 | TSHR (0.47) | CNR2HSD11B1HRH2 | |
| SCHEMBL5205358 | 0.68 | ALDH1A1 (0.45) | HSD11B1HRH2 | |
| SCHEMBL5201671 | 0.67 | ALDH1A1 (0.51) | CNR1CNR2HRH2MAPTHTT | |
| SCHEMBL6378962 | 0.67 | HRH2 (0.34) | CNR2HRH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |