SCHEMBL4861367

SCHEMBL4861367

CC(=CC=Cc1ccccc1)C(=O)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.40
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 2/20 0.40
GAA P10253 1/20 0.39
POLB P06746 1/20 0.39
HPGD P15428 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
GLA P06280 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
GRIK1 P39086 1/20 0.36
MCL1 Q07820 1/20 0.36
KMT2A Q03164 1/20 0.34
AKR1C3 P42330 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28881110 0.88 KDM4E (0.37) ALDH1A1KDM4ECYP2C9MAPT
SCHEMBL2363128 0.80 LMNA (0.46) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL435341 0.77 GAA (0.51) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL4355988 0.77 GAA (0.51) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL21219424 0.76 LMNA (0.45) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL22973244 0.76 HPGD (0.44) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL22973240 0.76 LMNA (0.47) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL8991908 0.75 LMNA (0.60) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL35777 0.75 LMNA (0.60) LMNAALDH1A1KDM4EGAAPOLB
SCHEMBL28116438 0.73 THRB (0.34) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2008517796-A 2008-05-29 JP claimed
EP-1836242-A2 A METHOD OF PRODUCING A SILICONE RUBBER ITEM AND THE PRODUCT OBTAINABLE BY THE METHOD Nanon A/S (DK) 2007-09-26 EP claimed
US-20070216061-A1 Method Of Producing A Silicone Rubber Item And The Product Obtainable By The Method NANON A/S (DK) 2007-09-20 US claimed
JP-2007504306-A 2007-03-01 JP claimed
US-20070004812-A1 Method of treating a rubber containing waste material NANON A/S (DK) 2007-01-04 US claimed
EP-1660570-A1 A METHOD OF TREATING A RUBBER CONTAINING WASTE MATERIAL Nanon A/S (DK) 2006-05-31 EP claimed
WO-2006045320-A2 A METHOD OF PRODUCING A SILICONE RUBBER ITEM AND THE PRODUCT OBTAINABLE BY THE METHOD NANON A/S (DK) 2006-05-04 WO claimed
WO-2005021625-A1 A METHOD OF TREATING A RUBBER CONTAINING WASTE MATERIAL NANON A/S (DK) 2005-03-10 WO claimed
EP-0958068-B1 NOVEL CLEANING PROCESS USING CARBON DIOXIDE AS A SOLVENT AND EMPLOYING MOLECULARLY ENGINEERED SURFACTANTS UNIV NORTH CAROLINA (US) 2003-07-23 EP claimed
US-5866005-A Cleaning process using carbon dioxide as a solvent and employing molecularly engineered surfactants THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-02-02 US claimed
US-5783082-A Cleaning process using carbon dioxide as a solvent and employing molecularly engineered surfactants UNIVERSITY OF NORTH CAROLINA (US) 1998-07-21 US claimed
EP-1836242-A2 A METHOD OF PRODUCING A SILICONE RUBBER ITEM AND THE PRODUCT OBTAINABLE BY THE METHOD Nanon A/S (DK) 2007-09-26 EP disclosed
US-20070216061-A1 Method Of Producing A Silicone Rubber Item And The Product Obtainable By The Method NANON A/S (DK) 2007-09-20 US disclosed
US-20070004812-A1 Method of treating a rubber containing waste material NANON A/S (DK) 2007-01-04 US disclosed
EP-1660570-A1 A METHOD OF TREATING A RUBBER CONTAINING WASTE MATERIAL Nanon A/S (DK) 2006-05-31 EP disclosed
EP-0958068-A1 NOVEL CLEANING PROCESS USING CARBON DIOXIDE AS A SOLVENT AND EMPLOYING MOLECULARLY ENGINEERED SURFACTANTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-11-24 EP disclosed
US-5944996-A MIXTURE WITH AMPHIPHILIC COMPOUND THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-08-31 US disclosed
US-5866005-A Cleaning process using carbon dioxide as a solvent and employing molecularly engineered surfactants THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-02-02 US disclosed
US-5783082-A Cleaning process using carbon dioxide as a solvent and employing molecularly engineered surfactants UNIVERSITY OF NORTH CAROLINA (US) 1998-07-21 US disclosed
WO-1997016264-A1 NOVEL CLEANING PROCESS USING CARBON DIOXIDE AS A SOLVENT AND EMPLOYING MOLECULARLY ENGINEERED SURFACTANTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1997-05-09 WO disclosed