Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862508 | 1.00 | SCN9A (0.42) | SCN9ASCN5AKCNH2DRD4HTR2A | |
| SCHEMBL4788153 | 0.83 | NOD1 (0.56) | SCN9ASCN5AKCNH2DRD4HTR2A | |
| SCHEMBL4786516 | 0.76 | MCHR1 (0.44) | SCN9ASCN5AKCNH2MCHR1EPHX2 | |
| SCHEMBL4788141 | 0.76 | BRAF (0.41) | SCN9ASCN5AKCNH2DRD4EGFR | |
| SCHEMBL4789166 | 0.74 | KCNH2 (0.51) | SCN9ASCN5AKCNH2DRD4HTR2A | |
| SCHEMBL4789084 | 0.69 | KDM4E (0.45) | KDM4EMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL4750039 | 0.68 | SCN9A (0.66) | SCN9ASCN5AKCNH2DRD4HTR2A | |
| SCHEMBL3678482 | 0.68 | MCHR1 (0.60) | MCHR1EPHX2MEN1KMT2AFAAH | |
| SCHEMBL11814856 | 0.67 | EPHX2 (0.52) | MCHR1EPHX2FAAHRAF1LIPE | |
| SCHEMBL4750025 | 0.67 | SCN9A (0.65) | SCN9ASCN5AKCNH2DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |