Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.41 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788153 | 0.79 | NOD1 (0.56) | SCN9AKCNH2SCN5ACHRM2CHRM1 | |
| SCHEMBL4862497 | 0.76 | SCN9A (0.42) | MCHR1SCN9AKCNH2SCN5ACHRM4 | |
| SCHEMBL4862508 | 0.76 | SCN9A (0.42) | MCHR1SCN9AKCNH2SCN5ACHRM4 | |
| SCHEMBL4789135 | 0.75 | KCNH2 (0.47) | SCN9AKCNH2SCN5ASIGMAR1TMEM97 | |
| SCHEMBL4789166 | 0.74 | KCNH2 (0.51) | MCHR1SCN9AKCNH2SCN5AEPHX2 | |
| SCHEMBL4786534 | 0.71 | MTNR1A (0.54) | MCHR1SCN9AKCNH2SCN5AMTNR1A | |
| SCHEMBL4788141 | 0.71 | BRAF (0.41) | SCN9AKCNH2SCN5A | |
| SCHEMBL4787954 | 0.69 | MEN1 (0.39) | — | |
| SCHEMBL4746920 | 0.68 | KCNH2 (0.61) | MCHR1SCN9AKCNH2SCN5AMTNR1A | |
| SCHEMBL3678482 | 0.68 | MCHR1 (0.60) | MCHR1TRPV1FAAHEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |