Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29597600 | 1.00 | POLB (0.67) | POLBHCAR2KDM4EHTTALOX15 | |
| Hydrochloric Acid SCHEMBL3050677 | 0.98 | POLB (0.64) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL2268149 | 0.84 | HCAR2 (0.48) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL22569116 | 0.82 | HTT (0.78) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL112388 | 0.80 | HCAR2 (1.00) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL29603529 | 0.80 | HCAR2 (1.00) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL28801075 | 0.80 | POLB (0.69) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL578591 | 0.78 | POLB (0.67) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL10461109 | 0.78 | HCAR2 (0.96) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL5839508 | 0.78 | POLB (0.67) | POLBHCAR2KDM4EHTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 346 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116580-B | Improved preparation method of nicergoline | 上海应用技术大学 | 2022-08-23 | — | — | CN | claimed |
| CN-113480532-B | Synthesis method of nicergoline | 福安药业集团重庆博圣制药有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-113480532-A | Synthesis method of nicergoline | 福安药业集团重庆博圣制药有限公司 | 2021-10-08 | — | — | CN | claimed |
| CN-104262246-A | 5-phenylnicotinamide Bcr-Abl inhibitors as well as preparation method and application thereof | UNIV XI AN JIAOTONG | 2015-01-07 | — | — | CN | claimed |
| CN-102276524-B | Preparation method of substituted picolinamide compounds | UNIV EASTERN LIAONING | 2014-03-05 | — | — | CN | claimed |
| CN-103159756-A | Novel preparation method for nicergoline | SHANDONG FANGMING PHARM GROUP | 2013-06-19 | — | — | CN | claimed |
| CN-102718761-A | Preparation method for nicergoline | ZHUHAI RUNDU PHARMACEUTICAL CO LTD | 2012-10-10 | — | — | CN | claimed |
| CN-102276524-A | Substituted picolinamide compounds and preparation method thereof | — | 2011-12-14 | — | — | CN | claimed |
| EP-4605089-A1 | COMPOUNDS USEFUL IN MODULATING EGFR AND PI3K | Mekanistic Therapeutics LLC (US) | 2025-08-27 | — | — | EP | disclosed |
| US-20250230144-A1 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2025-07-17 | — | — | US | disclosed |
| US-20240400555-A1 | Compounds, Compositions and Methods for Attenuation of Mammalian Translation of C-MYC or N-MYC Proteins of the MYC Proto-Oncogene Family of BHLH Transcription Factors | INITIAL THERAPEUTICS, INC. (US) | 2024-12-05 | — | — | US | disclosed |
| WO-2024226875-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR ATTENUATION OF MAMMALIAN TRANSLATION OF C-MYC OR N-MYC PROTEINS OF THE MYC PROTO-ONCOGENE FAMILY OF BHLH TRANSCRIPTION FACTORS | INITIAL THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |
| US-12110279-B2 | Triazolones, tetrazolones, and imidazolones, or their salts, and pharmaceutical compositions comprising the same | YUHAN CORPORATION (KR) | 2024-10-08 | — | — | US | disclosed |
| CN-118480001-A | C-Kit (V559D)/PDGFR beta double-target allosteric inhibitor and preparation method, pharmaceutical composition and application thereof | 贵州省天然产物研究中心 | 2024-08-13 | — | — | CN | disclosed |
| US-4753949-A | IMPROVES COGNITIVE FUNCTION, CALCIUM ANTAGONIST | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1988-06-28 | — | — | US | disclosed |
| EP-0251652-A2 | t-Butyl ergoline derivatives | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-01-07 | — | — | EP | disclosed |
| CN-86104086-A | The preparation method of 2-halogen nicergoline derivatives and its acid salt and new 2-halogen Varson class | — | 1986-12-17 | — | — | CN | disclosed |
| WO-1986006628-A1 | BENZAMIDE AND NICOTINAMIDE RADIOSENSITIZERS | SRI INTERNATIONAL (US) | 1986-11-20 | — | — | WO | disclosed |
| EP-0198311-A2 | Nicotin amides and their use as fungicidal agents | F. HOFFMANN-LA ROCHE AG (CH) | 1986-10-22 | — | — | EP | disclosed |
| EP-0192976-A1 | Compounds having antihyperlipemic activity, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER BIOCHEMIA ROBIN S.p.A. (IT) | 1986-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250230144-A1 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS | KCNJ4, KCNK4, KCNQ4 | POLB 4491/4885HCAR2 1924/4885KDM4E 882/4885 |
| US-12110279-B2 | Triazolones, tetrazolones, and imidazolones, or their salts, and pharmaceutical compositions comprising the same | VAPB, VAPA, FABP1 | POLB 2759/4885HCAR2 2481/4885KDM4E 4371/4885 |
| US-20240400555-A1 | Compounds, Compositions and Methods for Attenuation of Mammalian Translation of C-MYC or N-MYC Proteins of the MYC Proto-Oncogene Family of BHLH Transcription Factors | MYCBP, MYC, MYCBP2 | POLB 849/4885HCAR2 4800/4885KDM4E 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.