Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | BMP1 | P13497 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4864939 | 1.00 | MMP2 (0.49) | MMP2ADAMTS5ITGB3ITGA2BMAPK1 | |
| SCHEMBL4866783 | 0.93 | ITGB3 (0.49) | MMP2ITGB3ITGA2BMAPK1MMP9 | |
| SCHEMBL4866780 | 0.93 | ITGB3 (0.49) | MMP2ITGB3ITGA2BMAPK1MMP9 | |
| SCHEMBL5499234 | 0.90 | CTSL (0.49) | MMP2ADAMTS5ITGB3ITGA2BMAPK1 | |
| SCHEMBL5499235 | 0.90 | CTSL (0.49) | MMP2ADAMTS5ITGB3ITGA2BMAPK1 | |
| SCHEMBL4858174 | 0.85 | MMP2 (0.56) | MMP2ADAMTS5MMP9ALDH1A1MAPT | |
| SCHEMBL4858181 | 0.85 | MMP2 (0.56) | MMP2ADAMTS5MMP9ALDH1A1MAPT | |
| SCHEMBL3738168 | 0.83 | ITGB3 (0.47) | MMP2ADAMTS5ITGB3ITGA2BMAPK1 | |
| SCHEMBL3738167 | 0.83 | ITGB3 (0.47) | MMP2ADAMTS5ITGB3ITGA2BMAPK1 | |
| SCHEMBL3738170 | 0.83 | ITGB3 (0.46) | MMP2ADAMTS5ITGB3ITGA2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008520575-A | — | — | 2008-06-19 | — | — | JP | claimed |
| EP-1812012-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | Ceptyr, Inc. (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006055525-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | CEPTYR, INC. (US) | 2006-05-26 | — | — | WO | claimed |
| EP-1812012-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | Ceptyr, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006055525-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | CEPTYR, INC. (US) | 2006-05-26 | — | — | WO | disclosed |