Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | BCHE | P06276 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.53 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.53 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.53 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398692 | 0.88 | RAB9A (0.63) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL351853 | 0.88 | RAB9A (0.63) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL7660164 | 0.88 | RAB9A (0.63) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL1225684 | 0.88 | RAB9A (0.63) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL11813963 | 0.87 | MAPT (0.54) | RAB9AMAPTNPC1LMNABCHE | |
| Hydrochloric Acid SCHEMBL11814386 | 0.85 | MAPT (0.53) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL28814889 | 0.85 | PTGER1 (0.57) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL675700 | 0.85 | PTGER1 (0.57) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL27621963 | 0.84 | RAB9A (0.55) | RAB9AMAPTNPC1LMNABCHE | |
| SCHEMBL691503 | 0.82 | CA1 (0.53) | MAPTSMN1; SMN2NFKB1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141621-A | Oil-based fracturing fluid, multi-stage fracturing method and method for online monitoring productivity of reservoir intervals | 中国石油化工股份有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-104055755-A | Application of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone in preparation of antitumor drugs | UNIV ZHEJIANG SCIENCES | 2014-09-24 | — | — | CN | claimed |
| CN-102068420-B | Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases | UNIV EAST CHINA SCIENCE & TECH | 2012-07-04 | — | — | CN | claimed |
| CN-102068420-A | Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases | UNIV EAST CHINA SCIENCE & TECH | 2011-05-25 | — | — | CN | claimed |
| CN-101259118-B | Application of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone as PPAR gamma agonist | GUANGZHOU INST BIOMED & HEALTH | 2010-06-16 | — | — | CN | claimed |
| CN-101716166-A | Applications of 2', 4'-dihydroxyl-6'-methoxyl-3', 5'-dimethyl chalcone | UNIV EAST CHINA SCIENCE & TECH | 2010-06-02 | — | — | CN | claimed |
| CN-101259118-A | Application of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone as PPAR gamma agonist | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-09-10 | — | — | CN | claimed |
| WO-2023177194-A1 | NOVEL DIMETHYLCHALCONE DERIVATIVES | 중앙대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177191-A1 | COMPOSITION FOR PREVENTING OR TREATING FIBROTIC DISEASES, COMPRISING DIMETHYLCHALCONE DERIVATIVE AS ACTIVE INGREDIENT | 서울대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177191-A1 | COMPOSITION FOR PREVENTING OR TREATING FIBROTIC DISEASES, COMPRISING DIMETHYLCHALCONE DERIVATIVE AS ACTIVE INGREDIENT | 서울대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2023-08-10 | — | — | US | disclosed |
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2023-08-10 | — | — | US | disclosed |
| CN-115400106-A | Application of natural compound and composition thereof in removing senescent cells | 清华大学 | 2022-11-29 | — | — | CN | disclosed |
| CN-101259118-A | Application of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone as PPAR gamma agonist | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-09-10 | — | — | CN | disclosed |
| CN-101048651-A | Multifunctional reference system for use in analyte detection by fluorescence | HOFFMANN LA ROCHE (CH) | 2007-10-03 | — | — | CN | disclosed |
| CN-1275923-C | Use of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalkone as reversing agent for resistance of multiple tumours drugs | UNIV EAST CHINA SCIENCE & TECH (CN) | 2006-09-20 | — | — | CN | disclosed |
| CN-1680248-A | Use of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalkone as reversing agent for resistance of multiple tumours drugs | HUADONG SCIENCE & ENGINEERING (CN) | 2005-10-12 | — | — | CN | disclosed |
| US-20050148599-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2005-07-07 | — | — | US | disclosed |
| CN-1454895-A | Use of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone for preparing anticancer medicine | TUMOUR PREVENTION AND TREAT CT (CN) | 2003-11-12 | — | — | CN | disclosed |
| CN-1075632-A | Alkoxylated phenyl and coumarin derivative and application thereof | SCHAPER & BRUEMMER GMBH (DE) | 1993-09-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | LIPC, PC, CYP27A1 | RAB9A 3306/4885MAPT 1563/4885NPC1 189/4885 |
| US-20050148599-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | FLT1, VEGFA, FLT4 | RAB9A 2231/4885MAPT 341/4885NPC1 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.