Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.33 |
| ▸ | CPB1 | P15086 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14625961 | 0.89 | CYP3A4 (0.36) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL5346379 | 0.84 | CPB2 (0.40) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL4869118 | 0.83 | CYP2E1 (0.38) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL4869517 | 0.83 | PIK3CD (0.38) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL4865861 | 0.83 | CYP2C9 (0.43) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL4870253 | 0.83 | SYK (0.47) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL4868781 | 0.80 | CYP11B1 (0.43) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL14268984 | 0.80 | CYP2E1 (0.38) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL4172725 | 0.80 | HPGDS (0.38) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL7030913 | 0.80 | TLR8 (0.41) | CYP3A4CYP2C9CYP2C19CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163924-B2 | Ketolide derivatives | CHIRON CORPORATION (US) | 2007-01-16 | — | — | US | claimed |
| US-20050153905-A1 | Novel ketolide derivatives | CHIRON CORPORATION (US) | 2005-07-14 | — | — | US | claimed |
| US-7332476-B2 | Pyridyl substituted ketolide antibiotics | NOVARTIS AG (CH) | 2008-02-19 | — | — | US | disclosed |
| US-7163924-B2 | Ketolide derivatives | CHIRON CORPORATION (US) | 2007-01-16 | — | — | US | disclosed |
| EP-1618120-A2 | NOVEL KETOLIDE DERIVATIVES | CHIRON CORPORATION (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050153905-A1 | Novel ketolide derivatives | CHIRON CORPORATION (US) | 2005-07-14 | — | — | US | disclosed |
| US-20050009764-A1 | Pyridyl substituted ketolide antibiotics | CHIRON CORPORATION (US) | 2005-01-13 | — | — | US | disclosed |
| WO-2004096823-A2 | NOVEL KETOLIDE DERIVATIVES | CHIRON CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009764-A1 | Pyridyl substituted ketolide antibiotics | PKLR, KHK, PGD | CYP3A4 30/4885CYP2C9 10/4885CYP2C19 9/4885 |
| US-20050153905-A1 | Novel ketolide derivatives | KHK, CYP51A1, SI | CYP3A4 73/4885CYP2C9 40/4885CYP2C19 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.