SCHEMBL4867556

SCHEMBL4867556

COc1ccc(-c2ccnc3c2ccc2c(-c4ccc(OC)cc4)ccnc23)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 1/20 0.48
TLR8 Q9NR97 2/20 0.48
DYRK1A Q13627 2/20 0.47
GLO1 Q04760 1/20 0.46
KMT2A Q03164 4/20 0.44
MEN1 O00255 2/20 0.44
KDM4E B2RXH2 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
PDE3B Q13370 1/20 0.44
PDE3A Q14432 1/20 0.44
CKS1B P61024 2/20 0.44
SKP2 Q13309 2/20 0.44
ENPP3 O14638 1/20 0.44
ENPP1 P22413 1/20 0.44
CCNB2 O95067 1/20 0.44
CDK1 P06493 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6557994 0.93 MAPT (0.52) CLK4DYRK1AGLO1KMT2AMEN1
SCHEMBL29284767 0.92 TLR8 (0.43) CLK4TLR8DYRK1AGLO1KMT2A
SCHEMBL30964094 0.92 TLR8 (0.43) CLK4TLR8DYRK1AGLO1KMT2A
SCHEMBL8655989 0.89 CCR1 (0.54) CLK4GLO1KDM4ECYP3A4CYP2D6
SCHEMBL28083154 0.86 CLK4 (0.53) CLK4DYRK1AKMT2AMEN1KDM4E
SCHEMBL14552117 0.79 COMT (0.57) TLR8KMT2AMEN1CYP1A2CYP3A4
SCHEMBL30251801 0.77 BMP4 (0.61) CLK4TLR8KMT2AMEN1KDM4E
SCHEMBL7665284 0.77 BMP4 (0.61) CLK4TLR8KMT2AMEN1KDM4E
SCHEMBL4865360 0.77 LTA4H (0.49) CLK4TLR8DYRK1AKMT2AMEN1
SCHEMBL12566143 0.77 GLO1 (0.55) CLK4GLO1KMT2AKDM4ECKS1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7416791-B1 Osmium complexes and related organic light-emitting devices UNIVERSITY OF WASHINGTON (US) 2008-08-26 US claimed
US-20070105235-A1 Osmium-based oxygen sensor and pressure-sensitive paint WASHINGTON, UNIVERSITY OF 2007-05-10 US claimed
US-20070105235-A1 Osmium-based oxygen sensor and pressure-sensitive paint WASHINGTON, UNIVERSITY OF 2007-05-10 US disclosed