Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.46 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.46 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.42 |
| ▸ | WNT3A | P56704 | 3/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358195 | 0.84 | CTNNB1 (0.57) | YAP1TEAD4TEAD2LMNAGAA | |
| SCHEMBL1198865 | 0.83 | CTSS (0.48) | CTSSKAT6ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5375712 | 0.83 | YAP1 (0.46) | CTSSYAP1TEAD4TEAD2LMNA | |
| SCHEMBL4873112 | 0.83 | CTSS (0.55) | CTSSKAT6ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL283643 | 0.80 | KAT6A (0.49) | CTSSKAT6ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL28188796 | 0.80 | KAT6A (0.51) | CTSSKAT6ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL398909 | 0.78 | KAT6A (0.54) | CTSSKAT6ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9560994 | 0.78 | KAT6A (0.50) | CTSSKAT6ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5365219 | 0.78 | GSK3B (0.46) | CTSSYAP1TEAD4TEAD2LMNA | |
| SCHEMBL3058748 | 0.78 | CES2 (0.61) | KAT6AYAP1TEAD4TEAD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102573994-B | Novel bicyclic urea compounds | MERCK PATENT GMBH | 2015-06-24 | — | — | CN | disclosed |
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | REITER LAWRENCE A | 2008-03-27 | — | — | US | disclosed |
| EP-1794156-A2 | TROMBOPOIETIN RECEPTOR AGONISTS | Pfizer Products Incorporated (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033005-A2 | THROMBOPOIETIN RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | MPL, THPO, TBXA2R | CTSS 3979/4885KAT6A 3796/4885YAP1 3176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.