SCHEMBL4871848

SCHEMBL4871848

COc1cccc(Cn2c(-c3ccc4nc(-c5ccc(C(F)(F)F)cc5)ccc4c3)c(-c3ccccc3)c3sc(C(=O)O)cc32)c1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CSNK1D P48730 1/20 0.39
ALOX5AP P20292 2/20 0.39
MAPT P10636 1/20 0.38
PPARG P37231 5/20 0.38
GPR55 Q9Y2T6 1/20 0.37
ACP1 P24666 2/20 0.37
ROCK1 Q13464 1/20 0.37
MAPK8 P45983 1/20 0.37
MDM2 Q00987 1/20 0.36
PTGES O14684 1/20 0.36
CCR2 P41597 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4878878 0.92 LMNA (0.40) ALOX5APMAPTPPARGROCK1MAPK8
SCHEMBL4871792 0.91 PPARG (0.41) ALOX5APMAPTPPARGROCK1MAPK8
SCHEMBL4867738 0.91 PTGES (0.42) ALOX5APMAPTPPARGMAPK8PTGES
SCHEMBL4876397 0.89 MAPT (0.37) MAPTPPARGGPR55MAPK8PTGES
SCHEMBL4871839 0.87 ALOX5AP (0.40) CSNK1DALOX5APMDM2
SCHEMBL4868490 0.86 PPARG (0.43) MAPTPPARGMAPK8PTGESCCR2
SCHEMBL4878217 0.86 MAPT (0.39) MAPTPPARGMAPK8CCR2
SCHEMBL4875185 0.85 PPARG (0.40) ALOX5APMAPTPPARGACP1ROCK1
SCHEMBL4868814 0.84 EDNRB (0.39) ALOX5APMAPTPPARGMAPK8CCR2
SCHEMBL4868351 0.84 AKR1A1 (0.35) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080051384-A1 ANTIVIRAL AGENTS GENELABS TECHNOLOGIES, INC. 2008-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080051384-A1 ANTIVIRAL AGENTS EIF2AK2, MAVS, ZC3HAV1 CSNK1D 1492/4885ALOX5AP 3943/4885MAPT 4372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.