Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.57 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.57 |
| ▸ | PAM | P19021 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872094 | 1.00 | GRIK1 (0.57) | GRIK1GRIK2PAMHTR2APIN1 | |
| SCHEMBL4872085 | 1.00 | GRIK1 (0.57) | GRIK1GRIK2PAMHTR2APIN1 | |
| SCHEMBL4872068 | 1.00 | GRIK1 (0.57) | GRIK1GRIK2PAMHTR2APIN1 | |
| SCHEMBL27689553 | 0.86 | GRIK1 (0.62) | GRIK1GRIK2PAMHTR2APIN1 | |
| SCHEMBL27989732 | 0.86 | GRIK1 (0.62) | GRIK1GRIK2PAMHTR2APIN1 | |
| SCHEMBL29279724 | 0.81 | MMP1 (0.49) | GRIK1GRIK2PAMHTR2AMAOB | |
| SCHEMBL7903419 | 0.79 | HTR2A (0.59) | GRIK1GRIK2PAMHTR2AMAOB | |
| SCHEMBL4029905 | 0.79 | HTR2A (0.59) | GRIK1GRIK2PAMHTR2AMAOB | |
| SCHEMBL8087387 | 0.79 | GRIK1 (0.73) | GRIK1GRIK2PAMHTR2AGRIK3 | |
| SCHEMBL1865552 | 0.79 | GRIK1 (0.73) | GRIK1GRIK2PAMHTR2AGRIK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465752-B2 | Pentenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof | MERCK PATENT GMBH (DE) | 2008-12-16 | — | — | US | disclosed |
| US-20080015253-A1 | Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof | MERCK PATENT GMBH (DE) | 2008-01-17 | — | — | US | disclosed |
| EP-1742903-B1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| EP-1742903-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GmbH (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105723-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015253-A1 | Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof | ALOX5, GPR119, ALOX15B | GRIK1 917/4885GRIK2 1575/4885PAM 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.