Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SOD1 | P00441 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525877 | 0.81 | MAPT (0.59) | GAAKDM4EMAPTALDH1A1SOD1 | |
| SCHEMBL16060851 | 0.76 | PDE3B (0.45) | GAAKDM4EMAPTALDH1A1THRB | |
| SCHEMBL1013408 | 0.76 | KIF11 (0.44) | NOTUMDAOKDR | |
| SCHEMBL3261864 | 0.73 | KDM4E (0.46) | GAAKDM4EMAPTALDH1A1THRB | |
| SCHEMBL4522255 | 0.73 | GSTP1 (0.60) | GAAKDM4EMAPTNOTUMTDP1 | |
| SCHEMBL3561082 | 0.72 | MAPT (0.48) | GAAKDM4EMAPTALDH1A1THRB | |
| SCHEMBL30740090 | 0.69 | KDM4E (0.60) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11178624 | 0.69 | KDM4E (0.60) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11685438 | 0.68 | MCL1 (0.45) | GAAKDM4EMAPTALDH1A1THRB | |
| SCHEMBL11689636 | 0.68 | ALDH1A1 (0.47) | GAAKDM4EMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| US-20060287322-A1 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287322-A1 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | CNR1, CNR2, GPR18 | GAA 4572/4885KDM4E 3990/4885MAPT 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.