Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11598851 | 0.80 | SMN1; SMN2 (0.87) | SMN1; SMN2ALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL657644 | 0.79 | NR1H2 (0.61) | SMN1; SMN2ALDH1A1LMNATP53MAPT | |
| SCHEMBL1435798 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL831106 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL17279680 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL4865340 | 0.77 | JAK2 (0.49) | KDM4ELMNAMAPTIDO1 | |
| SCHEMBL11592234 | 0.76 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4ELMNAATR | |
| SCHEMBL6263112 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL15057162 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL12282613 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1HSD17B10KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560966-B1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INT CORPORATION (US) | 2021-01-06 | — | — | EP | disclosed |
| EP-3421036-B1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON CORP (US) | 2020-11-18 | — | — | EP | disclosed |
| US-10653674-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | VERSEON CORPORATION (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190142813-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2019-05-16 | — | — | US | disclosed |
| US-10251872-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2019-04-09 | — | — | US | disclosed |
| EP-3421036-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | Verseon Corporation (US) | 2019-01-02 | — | — | EP | disclosed |
| US-20180214418-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2018-08-02 | — | — | US | disclosed |
| US-20180214418-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2018-08-02 | — | — | US | disclosed |
| US-9963440-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | VERSEON CORPORATION (US) | 2018-05-08 | — | — | US | disclosed |
| US-9963440-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | VERSEON CORPORATION (US) | 2018-05-08 | — | — | US | disclosed |
| US-20160122333-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-05-05 | — | — | US | disclosed |
| US-20160122333-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-05-05 | — | — | US | disclosed |
| US-20160024047-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-20160024047-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2016-01-28 | — | — | US | disclosed |
| WO-2014145986-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20130040950-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON CORPORATION (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040950-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON CORPORATION (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2011126903-A2 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON, INC. (US) | 2011-10-13 | — | — | WO | disclosed |
| US-7361669-B2 | Compositions and method for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-20040157861-A1 | Compositions and methods for inhibiting TGF-beta | MILLENNIUM PHARMACEUTICALS, INC. | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190142813-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, SERPINB1 | SMN1; SMN2 3155/4885ALDH1A1 2728/4885HSD17B10 1964/4885 |
| US-20180214418-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | SMN1; SMN2 3708/4885ALDH1A1 3080/4885HSD17B10 2668/4885 |
| US-20160122333-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | SMN1; SMN2 3708/4885ALDH1A1 3080/4885HSD17B10 2668/4885 |
| US-10653674-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | TFPI, PLAT, SERPINC1 | SMN1; SMN2 3708/4885ALDH1A1 3080/4885HSD17B10 2668/4885 |
| US-10251872-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | SPINT2, PRSS1, SERPINB1 | SMN1; SMN2 3155/4885ALDH1A1 2728/4885HSD17B10 1964/4885 |
| US-20040157861-A1 | Compositions and methods for inhibiting TGF-beta | TGFB1, TGFB2, TGFBR1 | SMN1; SMN2 4032/4885ALDH1A1 2263/4885HSD17B10 1463/4885 |
| US-20160024047-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, SERPINB1 | SMN1; SMN2 3155/4885ALDH1A1 2728/4885HSD17B10 1964/4885 |
| US-20130040950-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | SMN1; SMN2 3708/4885ALDH1A1 3080/4885HSD17B10 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.