Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 13/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 13/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 10/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 10/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582649 | 0.81 | CHRNB2 (0.44) | CHRNB2CHRNA4HRH3CHRNB4CHRNA3 | |
| SCHEMBL649886 | 0.77 | CHRNB2 (0.52) | CHRNB2CHRNA4HRH3CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL654264 | 0.75 | CHRNB2 (0.51) | CHRNB2CHRNA4HRH3CHRNB4CHRNA3 | |
| SCHEMBL652471 | 0.74 | GPR119 (0.47) | USP30 | |
| SCHEMBL4875729 | 0.71 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14395684 | 0.70 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4113424 | 0.70 | HRH3 (0.65) | CHRNB2CHRNA4HRH3CHRNB4CHRNA3 | |
| SCHEMBL3657412 | 0.70 | HRH3 (0.65) | CHRNB2CHRNA4HRH3CHRNB4CHRNA3 | |
| SCHEMBL5376104 | 0.65 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5036675 | 0.65 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319106-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2008-01-15 | — | — | US | claimed |