Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 8/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514048 | 0.81 | CYP3A4 (0.47) | CYP3A4CYP1A2SLC22A12 | |
| SCHEMBL28775928 | 0.77 | CYP3A4 (0.45) | CYP3A4SLC22A12 | |
| SCHEMBL1969926 | 0.77 | PPARA (0.56) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL11128812 | 0.76 | GAA (0.53) | CYP3A4CYP1A2TSHRMRGPRX4PORCN | |
| SCHEMBL13291029 | 0.76 | IKBKB (0.48) | CYP3A4CYP1A2MRGPRX4 | |
| Ethyl Acetate SCHEMBL29093043 | 0.75 | ALDH1A1 (0.48) | CYP3A4CYP1A2MRGPRX4CCNCCDK8 | |
| SCHEMBL25005753 | 0.75 | ROCK2 (0.53) | CYP3A4MRGPRX4 | |
| SCHEMBL4029401 | 0.75 | GRM2 (0.55) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL9939335 | 0.75 | ABL1 (0.74) | — | |
| SCHEMBL3372231 | 0.74 | PPARA (0.49) | PPARACYP3A4ABCB11CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096916-A1 | Drugs And Prodrugs Useful The Treatment Of Energy Balance In Ruminants | PFIZER INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096916-A1 | Drugs And Prodrugs Useful The Treatment Of Energy Balance In Ruminants | PFIZER INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096916-A1 | Drugs And Prodrugs Useful The Treatment Of Energy Balance In Ruminants | PFIZER INC. (US) | 2008-04-24 | — | — | US | disclosed |
| EP-1824484-A1 | DRUGS AND PRODRUGS USEFUL FOR THE TREATMENT OF ENERGY BALANCE IN RUMINANTS | Pfizer Products Incorporated (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006054166-A1 | DRUGS AND PRODRUGS USEFUL FOR THE TREATMENT OF ENERGY BALANCE IN RUMINANTS | PFIZER PRODUCTS INC. (US) | 2006-05-26 | — | — | WO | disclosed |
| EP-1633747-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS PPAR-A ACTIVATORS | Pfizer Products Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| US-6987118-B2 | Tetrahydroisoquinoline derivatives as PPAR-alpha activators | PFIZER INC. (US) | 2006-01-17 | — | — | US | disclosed |
| US-20040248934-A1 | Tetrahydroisoquinoline derivatives as PPAR-alpha activators | PFIZER INC. | 2004-12-09 | — | — | US | disclosed |
| WO-2004103997-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS PPAR-α ACTIVATORS | PFIZER PRODUCTS INC. (US) | 2004-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248934-A1 | Tetrahydroisoquinoline derivatives as PPAR-alpha activators | PPARA, PPARG, PPARD | PPARA 1/4885CYP3A4 630/4885ABCB11 3099/4885 |
| US-20080096916-A1 | Drugs And Prodrugs Useful The Treatment Of Energy Balance In Ruminants | ALPP, PIGS, GYS2 | PPARA 614/4885CYP3A4 809/4885ABCB11 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.