Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8470525 | 0.84 | NPC1 (0.46) | CYP3A4CYP3A5MEN1KMT2AHTT | |
| SCHEMBL4883412 | 0.83 | CYP3A4 (0.52) | CYP3A4CYP3A5MEN1KMT2AHTT | |
| SCHEMBL4874915 | 0.83 | TACR1 (0.39) | MEN1KMT2AMAPTMAPK1DPP4 | |
| SCHEMBL13476441 | 0.81 | DPP4 (0.51) | CYP3A4CYP3A5HTTMAPTNPC1 | |
| SCHEMBL5157605 | 0.80 | CYP3A4 (0.47) | CYP3A4CYP3A5MEN1KMT2AHTT | |
| SCHEMBL13476445 | 0.80 | P2RX3 (0.47) | CYP3A4CYP3A5HTTMAPTNPC1 | |
| SCHEMBL5410711 | 0.79 | ATM (0.50) | MEN1KMT2AHTTMAPTNPC1 | |
| SCHEMBL13476476 | 0.79 | CYP3A4 (0.48) | CYP3A4CYP3A5MEN1KMT2AHTT | |
| SCHEMBL1760998 | 0.78 | CHRM2 (0.48) | CYP3A4CYP3A5MAPTALDH1A1MAPK1 | |
| SCHEMBL14593379 | 0.77 | CYP3A4 (0.50) | CYP3A4CYP3A5MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| US-7368448-B2 | 2-(arylalkoxy)-1-phenylethylamine derivatives as NK1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2008-05-06 | — | — | US | disclosed |
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | HTR1A, TPH1, HTR2A | CYP3A4 1008/4885CYP3A5 696/4885MEN1 1612/4885 |
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | HTR1A, HTR2A, TPH1 | CYP3A4 1329/4885CYP3A5 848/4885MEN1 1973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.