Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.39 |
| ▸ | GPX4 | P36969 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928876 | 0.83 | CACNA2D1 (0.55) | CACNA2D1CACNA1BCACNB1MEN1KMT2A | |
| SCHEMBL4879724 | 0.83 | CYP3A4 (0.52) | DPP4MEN1KMT2AMAPTMAPK1 | |
| Urea SCHEMBL27762549 | 0.80 | CACNA2D1 (0.52) | CACNA2D1CACNA1BCACNB1MEN1KMT2A | |
| SCHEMBL5154931 | 0.77 | HTR1A (0.52) | MAPT | |
| SCHEMBL5237104 | 0.71 | ADAMTS5 (0.52) | MAPTMAPK1 | |
| SCHEMBL21618404 | 0.70 | FAAH (0.53) | — | |
| SCHEMBL25247413 | 0.70 | MDM2 (0.43) | MEN1KMT2A | |
| SCHEMBL30433906 | 0.70 | MDM2 (0.43) | MEN1KMT2A | |
| SCHEMBL4883412 | 0.69 | CYP3A4 (0.52) | DPP4DPP8DPP9DPP7MEN1 | |
| SCHEMBL21733022 | 0.68 | DPP4 (0.47) | DPP4DPP8DPP9DPP7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| US-7368448-B2 | 2-(arylalkoxy)-1-phenylethylamine derivatives as NK1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2008-05-06 | — | — | US | disclosed |
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| CN-1956969-A | 2- ( arylalkoxy ) -1- phenylethylamine derivatives as nk1 antagonist and 5-serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | HTR1A, TPH1, HTR2A | TACR1 16/4885RPS6KB1 857/4885CACNA2D1 2778/4885 |
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | HTR1A, HTR2A, TPH1 | TACR1 28/4885RPS6KB1 533/4885CACNA2D1 2341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.